Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands
- Author
- TRAPANI, Giuseppe1 ; LAQUINTANA, Valentino1 ; SANNA, Enrico2 ; BIGGIO, Giovanni2 3 ; LISO, Gaetano1 ; DENORA, Nunzio1 ; TRAPANI, Adriana1 ; LOPEDOTA, Angela1 ; LATROFA, Andrea1 ; FRANCO, Massimo1 ; SERRA, Mariangela2 3 ; PISU, Maria Giuseppina2 3 ; FLORIS, Ivan2
[1] Dipartimento Farmaco-Chimico, Facoltà di Farmacia, Università degli Studi di Bari, Via Orabona 4, 70125 Bari, Italy
[2] Dipartimento di Biologia Sperimentale, Sezione di Neuroscienze, Università di Cagliari, Cittadella Universitaria Monserrato, SS 554 Km 4.5, Monserrato (Cagliari), Italy
[3] C.N.R. Institute of Neuroscience, Unit of Neuropharmacology, 09100 Cagliari, Italy - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 1, pp 292-305, 14 p ; ref : 40 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Animal Benzène dérivé Carboxamide Composé bicyclique Fixation biologique Homme Hétérocycle azote angulaire In vitro In vivo Ligand Neurostéroïde Rat Relation structure activité Récepteur benzodiazépinique périphérique Stéroïdogenèse Synthèse chimique Système nerveux Voie intrapéritonéale Imidazo[1,2-a]pyridine-3-acetamide(2-[4-chlorophényl-]N,N-dibutyl-6,8-dichloro) Imidazo[1,2-a]pyridine-3-acétamide(2-[4-chlorphényl]-6,8-dichloro-N-méthyl-N-phényl) Imidazopyridine Chlore Composé organique Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Animal Benzene derivatives Carboxamide Bicyclic compound Biological fixation Human Angular nitrogen heterocycle In vitro In vivo Ligand Neurosteroid Rat Structure activity relation Peripheral benzodiazepine receptor Steroidogenesis Chemical synthesis Nervous system Intraperitoneal administration Chlorine Organic compounds Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Animal Benceno derivado Carboxamida Compuesto bicíclico Fijación biológica Hombre Heterociclo nitrógeno angular In vitro In vivo Ligando Neurosteroido Rata Relación estructura actividad Receptor benzodiazepínico periférico Esteroidogénesis Síntesis química Sistema nervioso Vía intraperitoneal Cloro Compuesto orgánico Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09D Gabaergic and benzodiazepinic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16417324
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm049610q 
https://dx.doi.org/10.1021/jm049610q
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