Synthesis, biological evaluation, and molecular modeling of novel thioacridone derivatives related to the anticancer alkaloid acronycine
- Author
- DHEYONGERA, James P1 ; GELDENHUYS, Werner J1 2 ; DEKKER, Theodor G3 ; VAN DER SCHYF, Cornelis J1 2
[1] Pharmaceutical Chemistry, North West University, Potchefstroom 2520, South Africa
[2] Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106, United States
[3] Research Institute for Industrial Pharmacy, North West University, Potchefstroom 2520, South Africa - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 3, pp 689-698, 10 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acridine dérivé Acronine Agent intercalant Aire superficielle Alcaloïde Anticancéreux Cellule tumorale Coefficient partage Cytotoxicité DNA Diamine Fixation biologique Homme In vitro Leucémie Liaison covalente Lignée HL60 Lignée cellulaire Lipophilie Modèle moléculaire Modélisation Prédiction Relation structure activité Réfractivité Régression linéaire Régression multiple Synthèse chimique Testicule Thione Acridine-9-thione(1-[2-(diméthylamino)éthylamino]) Docking Fixation DNA Modélisation moléculaire QSAR
- Keyword (en)
- Acridine derivatives Acronine Intercalating agent Surface area Alkaloid Antineoplastic agent Tumor cell Partition coefficient Cytotoxicity DNA Diamine Biological fixation Human In vitro Leukemia Covalent bond HL60 cell line Cell line Lipophilicity Molecular model Modeling Prediction Structure activity relation Refractivity Linear regression Multiple regression Chemical synthesis Testicle Thione
- Keyword (es)
- Acronina Agente intercalante Area superficial Alcaloide Anticanceroso Célula tumoral Coeficiente repartición Citotoxicidad DNA Diamina Fijación biológica Hombre In vitro Leucemia Enlace covalente Línea HL60 Línea celular Lipofilia Modelo molecular Modelización Predicción Relación estructura actividad Refractividad Regresión lineal Regresión múltiple Síntesis química Testículo Tiona
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16427058
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.10.051 
https://dx.doi.org/10.1016/j.bmc.2004.10.051
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