Exploring QSAR of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists using FA and GFA techniques
- Author
- BHATTACHARYA, Prosenjit1 ; LEONARD, J. Thomas1 ; ROY, Kunal1
[1] Drug Theoretics and Cheminformatics Lab, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 4, pp 1159-1165, 7 p ; ref : 37 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Algorithme génétique Analyse factorielle Analyse régression Antagoniste Benzène dérivé Carboxamide Coefficient partage Cycle 5 chaînons Homme Hétérocycle soufre azote Lipophilie Modèle moléculaire Modélisation Propriété physicochimique Prédiction Relation structure activité Relation structure propriété Récepteur adénosinique A3 Régression multiple Sélectivité Thiadiazole dérivé Thiazole dérivé QSAR
- Keyword (en)
- Affinity Genetic algorithm Factor analysis Regression analysis Antagonist Benzene derivatives Carboxamide Partition coefficient Five membered ring Human Sulfur nitrogen heterocycle Lipophilicity Molecular model Modeling Physicochemical properties Prediction Structure activity relation Property structure relationship A3 adenosine receptor Multiple regression Selectivity Thiadiazole derivatives Thiazole derivatives
- Keyword (es)
- Afinidad Algoritmo genético Análisis factorial Análisis regresión Antagonista Benceno derivado Carboxamida Coeficiente repartición Ciclo 5 eslabones Hombre Heterociclo azufre nitrógeno Lipofilia Modelo molecular Modelización Propiedad fisicoquímica Predicción Relación estructura actividad Relación estructura propiedad Receptor adenosínico A3 Regresión múltiple Selectividad Tiadiazol derivado Tiazol derivado
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09F Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16455672
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.11.022 
https://dx.doi.org/10.1016/j.bmc.2004.11.022
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