Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers
- Author
- GRAULICH, A1 ; MERCIER, F1 ; SCUVEE-MOREAU, J2 ; SEUTIN, V2 ; LIEGEOIS, J.-F1 3
[1] University of Liège, Natural and Synthetic Drugs Research Center, Laboratory of Medicinal Chemistry, avenue de l'Hôpital, 1 (B36), 4000 Liège, Belgium
[2] University of Liège, Research Center for Cellular and Molecular Neurobiology, Laboratory of Pharmacology, avenue de l'Hôpital, 3 (B23), 4000 Liège, Belgium
[3] University of Liège, Laboratory of Physiology, avenue de l'Hôpital, 3 (B23), 4000 Liège, Belgium - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 4, pp 1201-1209, 9 p ; ref : 33 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Alcaloïde Ammonium quaternaire composé Animal Antagoniste canal potassium Benzène dérivé Cation organique Composé aromatique Composé bicyclique Electrophysiologie Enantiomère Encéphale Hétérocycle azote In vitro Neuromodulateur Neurone dopaminergique Rat Relation structure activité Synthèse chimique Canal potassium SK Isoquinoléinium composé Isoquinoléinium(2-aryl-6,7-diméthoxy-1-[3,4-diméthoxybenzyl]-2-méthyl-1,2,3,4-tétrahydro) iodure Laudanosine(N-alkyl) iodure Mammalia Rodentia Système nerveux central Vertebrata
- Keyword (en)
- Alkaloid Quaternary ammonium compound Animal Potassium channel antagonist Benzene derivatives Organic cation Aromatic compound Bicyclic compound Electrophysiology Enantiomer Encephalon Nitrogen heterocycle In vitro Neuromodulator Dopaminergic neuron Rat Structure activity relation Chemical synthesis SK potassium channel Mammalia Rodentia Central nervous system Vertebrata
- Keyword (es)
- Alcaloide Amonio cuaternario compuesto Animal Antagonista canal potasio Benceno derivado Catión orgánico Compuesto aromático Compuesto bicíclico Electrofisiología Enantiómero Encéfalo Heterociclo nitrógeno In vitro Neuromodulator Neurona dopaminérgica Rata Relación estructura actividad Síntesis química Mammalia Rodentia Sistema nervioso central Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B11 Miscellaneous
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16455677
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.11.025 
https://dx.doi.org/10.1016/j.bmc.2004.11.025
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