Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current
- Author
- NOVELLA ROMANELLI, Maria1 ; CERBAI, Elisabetta2 ; DEI, Silvia1 ; GUANDALINI, Luca1 ; MARTELLI, Cecilia1 ; MARTINI, Elisabetta1 ; SCAPECCHI, Serena1 ; TEODORI, Elisabetta1 ; MUGELLI, Alessandro2
[1] Dipartimento di Scienze Farmaceutiche, Università di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino (FI), Italy
[2] Dipartimento di Farmacologia Preclinica e Clinica, Università di Firenze, Viale Pieraccini 6, 50139 Firenze, Italy - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 4, pp 1211-1220, 10 p ; ref : 42 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Amine secondaire Amine tertiaire Animal Antagoniste Antiarythmique Canal ionique Cobaye Coeur Composé aromatique Composé bicyclique Hyperpolarisation Hétérocycle azote In vitro Lactame Myocyte Méthode patch clamp Rat Rythme cardiaque Synthèse chimique Zatébradine 3-Benzoazépin-2-one dérivé Mammalia Rodentia Vertebrata
- Keyword (en)
- Biological activity Secondary amine Tertiary amine Animal Antagonist Antiarrhythmic agent Ionic channel Guinea pig Heart Aromatic compound Bicyclic compound Hyperpolarization Nitrogen heterocycle In vitro Lactam Myocyte Patch clamp method Rat Heart rate Chemical synthesis Zatebradine Mammalia Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Amina secundaria Amina terciaria Animal Antagonista Antiarrítmico Canal iónico Cobayo Corazón Compuesto aromático Compuesto bicíclico Hiperpolarización Heterociclo nitrógeno In vitro Lactamo Miocito Método patch clamp Rata Ritmo cardíaco Síntesis química Zatebradina Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F02 Antiarythmic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16455678
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.11.017 
https://dx.doi.org/10.1016/j.bmc.2004.11.017
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