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Antitumor-active cobalt-alkyne complexes derived from acetylsalicylic acid: Studies on the mode of drug action

Author
OTT, Ingo1 ; SCHMIDT, Kathrin1 ; KIRCHER, Brigitte2 ; SCHUMACHER, Petra2 ; WIGLENDA, Thomas1 ; GUST, Ronald1
[1] Institute of Pharmacy, Free University of Berlin, Königin Luise Str. 2+4, 14195 Berlin, Germany
[2] Laboratory for Tumor and Immunobiology, Department of Hematology and Oncology, University Hospital of Innsbruck, Austria
Source

Journal of medicinal chemistry (Print). 2005, Vol 48, Num 2, pp 622-629, 8 p ; ref : 34 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Anticancéreux Cellule tumorale Composé acétylénique Coordinat organique Cyclooxygenase 1 Cyclooxygenase 2 Cytotoxicité DNA Epithélium Fixation biologique Glande mammaire Glutathione reductase (NADPH) Homme In vitro Inhibiteur enzyme Interaction moléculaire Lignée cellulaire Lipophilie Mécanisme action Propriété physicochimique Relation structure activité Relation structure propriété Salicylés Synthèse chimique Acétylsalicylique acide ester propargyle Benzoïque acide(2-acétoxy) ester propargyle Lignée MCF7 Lignée MDAMB231 Cobalt Carbonyle Complexe Enzyme Métal transition Carbonyle Complexe Oxidoreductases
Keyword (en)
Antineoplastic agent Tumor cell Acetylenic compound Organic ligand Cyclooxygenase 1 Cyclooxygenase 2 Cytotoxicity DNA Epithelium Biological fixation Mammary gland Glutathione reductase (NADPH) Human In vitro Enzyme inhibitor Molecular interaction Cell line Lipophilicity Mechanism of action Physicochemical properties Structure activity relation Property structure relationship Salicylates Chemical synthesis Cobalt Carbonyl Complexes Enzyme Transition metal Carbonyl Complexes Oxidoreductases
Keyword (es)
Anticanceroso Célula tumoral Compuesto acetilénico Ligando orgánico Cyclooxygenase 1 Cyclooxygenase 2 Citotoxicidad DNA Epitelio Fijación biológica Glándula mamaria Glutathione reductase (NADPH) Hombre In vitro Inhibidor enzima Interacción molecular Línea celular Lipofilia Mecanismo acción Propiedad fisicoquímica Relación estructura actividad Relación estructura propiedad Salicilatos Síntesis química Cobalto Carbonilo Complejo Enzima Metal transición Carbonilo Complejo Oxidoreductases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
16456605

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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