Quinols as novel therapeutic agents. 2.1 4-(1-arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents
- Author
- BERRY, Jane M1 ; BRADSHAW, Tracey D1 ; FICHTNER, Iduna2 ; REN, Ruobo3 ; SCHWALBE, Carl H3 ; WELLS, Geoffrey1 ; CHEW, Eng-Hui1 ; STEVENS, Malcolm F. G1 ; WESTWELL, Andrew D1
[1] Cancer Research U.K. Experimental Cancer Chemotherapy Research Group, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom
[2] Max-Delbrück-Center for Molecular Medicine Berlin-Buch, Robert-Rössle-Strasse 10, Postfach 74 02 38, 13092 Berlin, Germany
[3] Aston Pharmacy School, Aston University, Birmingham, B4 7ET, United Kingdom - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 2, pp 639-644, 6 p ; ref : 15 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Alcool tertiaire Animal Anticancéreux Cellule tumorale Chimiothérapie Composé aromatique Composé bicyclique Composé monocyclique Cytotoxicité Côlon Diffraction RX Diénone Glande mammaire Homme Hétérocycle azote In vitro In vivo Indole dérivé Lignée cellulaire Mécanisme action Pathologie expérimentale Relation structure activité Souris Sulfonamide Synthèse chimique Traitement Tumeur maligne Voie intrapéritonéale Cyclohexa-2,5-diénone(4-[1-(benzènesulfonyl)indol-2-yl]-4-hydroxy) Cyclohexa-2,5-diénone(4-[1-benzènesulfonyl-6-fluoroindol-2-yl]-4-hydroxy) Lignée HCT116 Lignée MDAMB435 Mammalia Rodentia Vertebrata
- Keyword (en)
- Tertiary alcohol Animal Antineoplastic agent Tumor cell Chemotherapy Aromatic compound Bicyclic compound Monocyclic compound Cytotoxicity Colon X ray diffraction Dienone Mammary gland Human Nitrogen heterocycle In vitro In vivo Indole derivatives Cell line Mechanism of action Experimental disease Structure activity relation Mouse Sulfonamide Chemical synthesis Treatment Malignant tumor Intraperitoneal administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Alcohol terciario Animal Anticanceroso Célula tumoral Quimioterapia Compuesto aromático Compuesto bicíclico Compuesto monocíclico Citotoxicidad Colón Difracción RX Dienona Glándula mamaria Hombre Heterociclo nitrógeno In vitro In vivo Indol derivado Línea celular Mecanismo acción Patología experimental Relación estructura actividad Ratón Sulfonamida Síntesis química Tratamiento Tumor maligno Vía intraperitoneal Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16456608
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm040859h 
https://dx.doi.org/10.1021/jm040859h
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