Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics
- Author
- HAIYING SUN1 ; NIKOLOVSKA-COLESKA, Zaneta1 ; JIANYONG CHEN1 ; YANG, Chao-Yie1 ; TOMITA, York2 ; HONGGUANG PAN2 ; YOSHIOKA, Yoshiko2 ; KRAJEWSKI, Krzysztof3 ; ROLLERS, Peter P3 ; SHAOMENG WANG1
[1] University of Michigan Comprehensive Cancer Center, Departments of Internal Medicine and Medicinal Chemistry, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0934, United States
[2] Lombardi Cancer Center, Georgetown University Medical Center, W213 Research Building, 3970 Reservoir Road NW., Washington, DC 20057-1469, United States
[3] Laboratory of Medicinal Chemistry, National Cancer Institute, FCRDC, Bldg 376, Frederick, MD 21702-1201, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 3, pp 793-797, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Apoptose Ciblage Composé peptidomimétique Fixation biologique In vitro Peptide Relation structure activité Synthèse chimique Tripeptide Prolinamide([2-aminobutyryl-valyl]-N-benzhydryl) Proline dérivé Protéine XIAP Protéine smac Valine dérivé
- Keyword (en)
- Antineoplastic agent Apoptosis Targeting Peptidomimetic compound Biological fixation In vitro Peptides Structure activity relation Chemical synthesis Tripeptide Second mitochondria derived activator of caspase protein
- Keyword (es)
- Anticanceroso Apoptosis Blancado Compuesto peptidomimético Fijación biológica In vitro Péptido Relación estructura actividad Síntesis química Tripéptido
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16478224
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.11.008 
https://dx.doi.org/10.1016/j.bmcl.2004.11.008
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