Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2
- Author
- WILLIAMSON, Douglas S1 ; PARRATT, Martin J1 ; JACKSON, Philip S1 ; LOCKIE, Andrea M1 ; MURRAY, James B1 ; NUNNS, Claire L1 ; POWLES, Jenifer1 ; ROBERTSON, Alan1 ; SURGENOR, Allan E1 ; TORRANCE, Christopher J1 ; BOWER, Justin F1 ; MOORE, Jonathan D1 ; RICHARDSON, Christine M1 ; DOKURNO, Pawel1 ; CANSFIELD, Andrew D1 ; FRANCIS, Geraint L1 ; HEBDON, Richard J1 ; HOWES, Rob1
[1] Vernalis (R&D) Ltd, Granta Park, Great Abington, Cambridge CB1 6GB, United Kingdom - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 4, pp 863-867, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Cellule tumorale Cyclin dependent kinase Cytotoxicité Côlon Homme Hétérocycle azote angulaire In vitro Inhibiteur enzyme Protein kinase Relation structure activité Sulfonamide Synthèse chimique Sélectivité Transduction signal Lignée HCT116 Pyrazolo[1,5-a]pyrimidine(5-[4-aminocyclohexylamino]-7-[4-(diméthylsulfamoyl)anilino]-3-isopropyl) Pyrazolopyrimidine Enzyme Transferases
- Keyword (en)
- Antineoplastic agent Tumor cell Cyclin dependent kinase Cytotoxicity Colon Human Angular nitrogen heterocycle In vitro Enzyme inhibitor Protein kinase Structure activity relation Sulfonamide Chemical synthesis Selectivity Signal transduction Enzyme Transferases
- Keyword (es)
- Anticanceroso Célula tumoral Cyclin dependent kinase Citotoxicidad Colón Hombre Heterociclo nitrógeno angular In vitro Inhibidor enzima Protein kinase Relación estructura actividad Sulfonamida Síntesis química Selectividad Transducción señal Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16480654
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.12.073 
https://dx.doi.org/10.1016/j.bmcl.2004.12.073
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