Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13)
- Author
- KIM, Soong-Hoon1 ; PUDZIANOWSKI, Andrew T1 ; LEAVITT, Kenneth J1 ; BARBOSA, Joseph1 ; MCDONNELL, Patricia A1 ; METZLER, William J1 ; RANKIN, Bruce M1 ; LIU, Richard1 ; VACCARO, Wayne1 ; PITTS, William1
[1] Bristol Myers Squibb Co., Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08560, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 4, pp 1101-1106, 6 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Barbituriques In vitro Inhibiteur enzyme Interaction moléculaire Metalloendopeptidases Modèle moléculaire Modélisation Pyrimidine dérivé Relation structure activité Spirane Synthèse chimique Sélectivité Zinc Complexe 2,4,7-Triazaspiro[5.4]décane-1,2,5,8-tétraone(7-[4-phénoxyphényl]) Matrix metalloproteinase 13 Enzyme Hydrolases Peptidases
- Keyword (en)
- Barbiturates In vitro Enzyme inhibitor Molecular interaction Metalloendopeptidases Molecular model Modeling Pyrimidine derivatives Structure activity relation Spiran Chemical synthesis Selectivity Zinc Complexes Enzyme Hydrolases Peptidases
- Keyword (es)
- Barbitúricos In vitro Inhibidor enzima Interacción molecular Metalloendopeptidases Modelo molecular Modelización Pirimidina derivado Relación estructura actividad Espirano Síntesis química Selectividad Zinc Complejo Enzima Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16480699
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.12.016 
https://dx.doi.org/10.1016/j.bmcl.2004.12.016
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