Synthesis and monoamine transporter affinity of new 2β-carbomethoxy-3β-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency
- Author
- TAMAGNAN, Gilles1 2 ; ALAGILLE, David1 ; XING FU1 ; KULA, Nora S3 ; BALDESSARINI, Ross J3 ; INNIS, Robert B1 ; BALDWIN, Ronald M1
[1] Department of Psychiatry, Yale University and VA Connecticut/116A2, 950 Campbell Avenue, West Haven, CT 06516, United States
[2] Institute for Neurodegenerative Disorders, 60 Temple Street, Suite 8A, New Haven, CT 06510, United States
[3] Department of Psychiatry and Neuroscience Program, Harvard Medical School and Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478-9106, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 4, pp 1131-1133, 3 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Amine biogène Antagoniste In vitro Neurotransmetteur Relation structure activité Synthèse chimique Sélectivité Sérotonine Thiophène dérivé Transport biologique Transport membranaire Tropane dérivé 8-Azabicyclo[3.2.1]octane dérivé Transporteur sérotonine Tropane-2β-carboxylique acide(3β-[4-(3-thiényl)phényl]) ester méthyle
- Keyword (en)
- Affinity Biogenic amine Antagonist In vitro Neurotransmitter Structure activity relation Chemical synthesis Selectivity Serotonin Thiophene derivatives Biological transport Membrane transport Tropane derivatives
- Keyword (es)
- Afinidad Amina biógena Antagonista In vitro Neurotransmisor Relación estructura actividad Síntesis química Selectividad Serotonina Tiofeno derivado Transporte biológico Transporte membranal
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09C Serotoninergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16480705
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.12.014 
https://dx.doi.org/10.1016/j.bmcl.2004.12.014
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