Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors
- Author
- YONGXIN HAN1 ; GIROUX, André1 ; TAWA, Paul2 ; NICHOLSON, Donald W2 ; ZAMBONI, Robert J1 ; COLUCCI, John1 ; BAYLY, Christopher I1 ; MCKAY, Daniel J1 ; ROY, Sophie2 ; XANTHOUDAKIS, Steve2 ; VAILLANCOURT, John2 ; RASPER, Dita M2 ; TAM, John2
[1] Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada & Co., PO Box 1005, Pointe-Claire-Dorval, Quebec, H9R 4P8, Canada
[2] Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada & Co., PO Box 1005, Pointe-Claire-Dorval, Quebec, H9R 4P8, Canada - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 4, pp 1173-1180, 8 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Amide Animal Antiapoptotique Caspase Composé non peptide Cysteine endopeptidases In vitro In vivo Inhibiteur enzyme Isozyme Oxadiazole dérivé Pyrazine dérivé Rat Synthèse chimique Sélectivité 1,2,5-Oxadiazole dérivé Aspartamide dérivé Aspartique acide dérivé Inhibiteur caspase Pyrazin-2-one dérivé Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (en)
- Biological activity Amides Animal Antiapoptotic agent Caspase Non peptide compound Cysteine endopeptidases In vitro In vivo Enzyme inhibitor Isozyme Oxadiazole derivatives Pyrazine derivatives Rat Chemical synthesis Selectivity Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Animal Antiapoptosis Caspase Compuesto no péptido Cysteine endopeptidases In vitro In vivo Inhibidor enzima Isozima Oxadiazol derivado Pirazina derivado Rata Síntesis química Selectividad Enzima Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16480714
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.12.006 
https://dx.doi.org/10.1016/j.bmcl.2004.12.006
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