Synthesis and biological evaluation of new clofibrate analogues as potential PPARα agonists
- Author
- PERRONE, Maria Grazia1 ; SANTANDREA, Ernesto1 ; DELL'UOMO, Natalina2 ; GIANNESSI, Fabio2 ; MILAZZO, Ferdinando Maria2 ; SCIARRONI, Anna Floriana2 ; SCILIMATI, Antonio1 ; TORTORELLA, Vincenzo1
[1] Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Via E.Orabona 4, 70125 Bari, Italy
[2] Ricerca e Sviluppo, Sigma tau Industrie Farmaceutiche S.p.A., Via Pontina km 30.400, 00040 Pomezia, Italy - Source
European journal of medicinal chemistry. 2005, Vol 40, Num 2, pp 143-154, 12 p ; ref : 24 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Clofibrate analogues Dyslipidemia Ethyl 2-(4-chlorophenoxy)-3-hydroxyalkanoates Ethyl 2-(4-chlorophenoxy)-3-oxoalkanoates
- Keyword (fr)
- Affinité Agoniste Clofibrate Composé aliphatique Cétoéther Hydroxyéther In vitro Relation structure activité Récepteur PPAR-α Synthèse chimique Acide alcanoïque(2-[4-chlorophénoxy]-3-hydroxy) ester éthyle Acide alcanoïque(2-[4-chlorophénoxy]-3-oxo) ester éthyle Chlore Composé organique
- Keyword (en)
- Affinity Agonist Clofibrate Aliphatic compound Ketoether Hydroxyether In vitro Structure activity relation PPAR-α receptor Chemical synthesis Chlorine Organic compounds
- Keyword (es)
- Afinidad Agonista Clofibrato Compuesto alifático Cetoéter Hidroxieter In vitro Relación estructura actividad Receptor PPAR-α Síntesis química Cloro Compuesto orgánico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16517695
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1016/j.ejmech.2004.09.018 
https://dx.doi.org/10.1016/j.ejmech.2004.09.018
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:28:\"10.1016\/j.ejmech.2004.09.018\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:92:\"Synthesis and biological evaluation of new clofibrate analogues as potential PPAR\u03b1 agonists\";s:9:\"\u0000*\u0000jtitle\";s:39:\"European journal of medicinal chemistry\";s:9:\"\u0000*\u0000stitle\";s:17:\"Eur. j. med. chem\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"40\";s:8:\"\u0000*\u0000issue\";s:1:\"2\";s:8:\"\u0000*\u0000spage\";s:3:\"143\";s:8:\"\u0000*\u0000epage\";s:3:\"154\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0223-5234\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"PERRONE\";s:10:\"\u0000*\u0000aufirst\";s:12:\"Maria Grazia\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:19:\"SANTANDREA, Ernesto\";i:1;s:19:\"DELL'UOMO, Natalina\";i:2;s:16:\"GIANNESSI, Fabio\";i:3;s:25:\"MILAZZO, Ferdinando Maria\";i:4;s:24:\"SCIARRONI, Anna Floriana\";i:5;s:18:\"SCILIMATI, Antonio\";i:6;s:20:\"TORTORELLA, Vincenzo\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"EJMCA5\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:92:\"Synthesis and biological evaluation of new clofibrate analogues as potential PPAR\u03b1 agonists\";s:8:\"\u0000*\u0000place\";s:6:\"Oxford\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"12\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:28:\"10.1016\/j.ejmech.2004.09.018\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:92:\"Synthesis and biological evaluation of new clofibrate analogues as potential PPAR\u03b1 agonists\";s:9:\"\u0000*\u0000jtitle\";s:39:\"European journal of medicinal chemistry\";s:9:\"\u0000*\u0000stitle\";s:17:\"Eur. j. med. chem\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"40\";s:8:\"\u0000*\u0000issue\";s:1:\"2\";s:8:\"\u0000*\u0000spage\";s:3:\"143\";s:8:\"\u0000*\u0000epage\";s:3:\"154\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0223-5234\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"PERRONE\";s:10:\"\u0000*\u0000aufirst\";s:12:\"Maria Grazia\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:19:\"SANTANDREA, Ernesto\";i:1;s:19:\"DELL'UOMO, Natalina\";i:2;s:16:\"GIANNESSI, Fabio\";i:3;s:25:\"MILAZZO, Ferdinando Maria\";i:4;s:24:\"SCIARRONI, Anna Floriana\";i:5;s:18:\"SCILIMATI, Antonio\";i:6;s:20:\"TORTORELLA, Vincenzo\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"EJMCA5\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:92:\"Synthesis and biological evaluation of new clofibrate analogues as potential PPAR\u03b1 agonists\";s:8:\"\u0000*\u0000place\";s:6:\"Oxford\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"12\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:28:\"10.1016\/j.ejmech.2004.09.018\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:28:\"10.1016\/j.ejmech.2004.09.018\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:92:\"Synthesis and biological evaluation of new clofibrate analogues as potential PPAR\u03b1 agonists\";s:9:\"\u0000*\u0000jtitle\";s:39:\"European journal of medicinal chemistry\";s:9:\"\u0000*\u0000stitle\";s:17:\"Eur. j. med. chem\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"40\";s:8:\"\u0000*\u0000issue\";s:1:\"2\";s:8:\"\u0000*\u0000spage\";s:3:\"143\";s:8:\"\u0000*\u0000epage\";s:3:\"154\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0223-5234\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"PERRONE\";s:10:\"\u0000*\u0000aufirst\";s:12:\"Maria Grazia\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:19:\"SANTANDREA, Ernesto\";i:1;s:19:\"DELL'UOMO, Natalina\";i:2;s:16:\"GIANNESSI, Fabio\";i:3;s:25:\"MILAZZO, Ferdinando Maria\";i:4;s:24:\"SCIARRONI, Anna Floriana\";i:5;s:18:\"SCILIMATI, Antonio\";i:6;s:20:\"TORTORELLA, Vincenzo\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"EJMCA5\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:92:\"Synthesis and biological evaluation of new clofibrate analogues as potential PPAR\u03b1 agonists\";s:8:\"\u0000*\u0000place\";s:6:\"Oxford\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"12\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:28:\"10.1016\/j.ejmech.2004.09.018\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:92:\"Synthesis and biological evaluation of new clofibrate analogues as potential PPAR\u03b1 agonists\";s:9:\"\u0000*\u0000jtitle\";s:39:\"European journal of medicinal chemistry\";s:9:\"\u0000*\u0000stitle\";s:17:\"Eur. j. med. chem\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"40\";s:8:\"\u0000*\u0000issue\";s:1:\"2\";s:8:\"\u0000*\u0000spage\";s:3:\"143\";s:8:\"\u0000*\u0000epage\";s:3:\"154\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0223-5234\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"PERRONE\";s:10:\"\u0000*\u0000aufirst\";s:12:\"Maria Grazia\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:19:\"SANTANDREA, Ernesto\";i:1;s:19:\"DELL'UOMO, Natalina\";i:2;s:16:\"GIANNESSI, Fabio\";i:3;s:25:\"MILAZZO, Ferdinando Maria\";i:4;s:24:\"SCIARRONI, Anna Floriana\";i:5;s:18:\"SCILIMATI, Antonio\";i:6;s:20:\"TORTORELLA, Vincenzo\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"EJMCA5\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:92:\"Synthesis and biological evaluation of new clofibrate analogues as potential PPAR\u03b1 agonists\";s:8:\"\u0000*\u0000place\";s:6:\"Oxford\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"12\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:28:\"10.1016\/j.ejmech.2004.09.018\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:92:\"Synthesis and biological evaluation of new clofibrate analogues as potential PPAR\u03b1 agonists\";s:9:\"\u0000*\u0000jtitle\";s:39:\"European journal of medicinal chemistry\";s:9:\"\u0000*\u0000stitle\";s:17:\"Eur. j. med. chem\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"40\";s:8:\"\u0000*\u0000issue\";s:1:\"2\";s:8:\"\u0000*\u0000spage\";s:3:\"143\";s:8:\"\u0000*\u0000epage\";s:3:\"154\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0223-5234\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"PERRONE\";s:10:\"\u0000*\u0000aufirst\";s:12:\"Maria Grazia\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:19:\"SANTANDREA, Ernesto\";i:1;s:19:\"DELL'UOMO, Natalina\";i:2;s:16:\"GIANNESSI, Fabio\";i:3;s:25:\"MILAZZO, Ferdinando Maria\";i:4;s:24:\"SCIARRONI, Anna Floriana\";i:5;s:18:\"SCILIMATI, Antonio\";i:6;s:20:\"TORTORELLA, Vincenzo\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"EJMCA5\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:92:\"Synthesis and biological evaluation of new clofibrate analogues as potential PPAR\u03b1 agonists\";s:8:\"\u0000*\u0000place\";s:6:\"Oxford\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"12\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
