Synthesis and biological evaluation of lipophilic Ca1a2L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1
- Author
- EL OUALID, Farid1 ; BAKTAWAR, Jayand1 ; LEROY, Ingrid M2 ; VAN DEN ELST, Hans1 ; COHEN, Louis H2 ; VAN DER MAREL, Gijs A1 ; OVERKLEEFT, Herman S1 ; OVERHAND, Mark1
[1] Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, PO Box 9502, 2300 RA Leiden, Netherlands
[2] TNO Prevention and Health, Gaubius Laboratory, PO Box 2215, 2301 CE Leiden, Netherlands - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 5, pp 1463-1475, 13 p ; ref : 14 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide uronique Aminoacide soufré Anticancéreux Composé lipophile Composé peptidomimétique Geranylgeranyl-diphosphate geranylgeranyltransferase Gène onc Gène ras In vitro Inhibiteur enzyme Relation structure activité Synthèse chimique α-Aminoacide Cystéine dérivé Glucopyranosiduronique acide dérivé Leucine dérivé Enzyme Transferases
- Keyword (en)
- Uronic acid Sulfur containing aminoacid Antineoplastic agent Lipophilic compound Peptidomimetic compound Geranylgeranyl-diphosphate geranylgeranyltransferase Onc gene Ras gene In vitro Enzyme inhibitor Structure activity relation Chemical synthesis α-Aminoacid Enzyme Transferases
- Keyword (es)
- Acido urónico Aminoácido azufrado Anticanceroso Compuesto lipófilo Compuesto peptidomimético Geranylgeranyl-diphosphate geranylgeranyltransferase Gen onc Gen ras In vitro Inhibidor enzima Relación estructura actividad Síntesis química α-Aminoácido Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16518147
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.12.035 
https://dx.doi.org/10.1016/j.bmc.2004.12.035
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