Synthesis of per-sulfated flavonoids using 2,2,2-trichloro ethyl protecting group and their factor Xa inhibition potential
- Author
- GUNNARSSON, Gunnar T1 ; RIAZ, Muhammad1 ; ADAMS, Joanna1 ; DESAI, Umesh R1
[1] Department of Medicinal Chemistry, Institute for Structural Biology and Drug Discovery, Virginia Commonwealth University, 800 East Leigh Street, Suite 212, Richmond, VA 23219, United States - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 5, pp 1783-1789, 7 p ; ref : 39 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticoagulant Antithrombine Chlore Composé organique Coagulation Factor Xa Flavone dérivé Flavonoïde Groupe protecteur In vitro Inhibiteur enzyme Relation structure activité Sulfate organique Synthèse chimique 1-Benzopyrane dérivé Ethanesulfonique acide(trichloro) chlorure Flavone(poly-sulfonatooxy) Enzyme Hydrolases Peptidases Serine endopeptidases
- Keyword (en)
- Anticoagulant Antithrombin Chlorine Organic compounds Coagulation Factor Xa Flavone derivatives Flavonoid Protecting group In vitro Enzyme inhibitor Structure activity relation Organic sulfate Chemical synthesis Enzyme Hydrolases Peptidases Serine endopeptidases
- Keyword (es)
- Anticoagulante Antitrombina Cloro Compuesto orgánico Coagulation Factor Xa Flavona derivado Flavonoide Grupo protector In vitro Inhibidor enzima Relación estructura actividad Sulfato orgánico Síntesis química Enzima Hydrolases Peptidases Serine endopeptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02G Blood. Blood coagulation. Reticuloendothelial system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16518180
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.11.060 
https://dx.doi.org/10.1016/j.bmc.2004.11.060
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