Synthesis and cytotoxic evaluation of novel spirohydantoin derivatives of the dihydrothieno[2,3-b]naphtho-4,9-dione system
- Author
- GOMEZ-MONTERREY, Isabel1 ; SANTELLI, Giovanni2 ; CAMPIGLIA, Pietro1 ; CALIFANO, Daniela2 ; FALASCONI, Fabiano2 ; PISANO, Claudio3 ; VESCI, Loredana3 ; LAMA, Teresa1 ; GRIECO, Paolo1 ; NOVELLINO, Ettore1
[1] Dipartimento di Chimica Farmaceutica e Tossicologica, University of Naples Federico II, Napoli, Italy
[2] Oncologia Sperimentale E, Istituto dei Tumori Fondazione G. Pascale, Napoli, Italy
[3] Area di Ricerca Oncologica-R&S, Sigma-Tau S.p.A., Pomezia, Roma, Italy - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 4, pp 1152-1157, 6 p ; ref : 18 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Cellule tumorale Composé aromatique Composé tétracyclique Cytotoxicité Homme Hydantoïnes Hétérocycle soufre azote In vitro Lignée cellulaire Quinone Relation structure activité Spirane Synthèse chimique Spiro[imidazole-5:3p-thiéno[2,3-b]naphtène-2,4,4p,9p-tétraone] dérivé
- Keyword (en)
- Antineoplastic agent Tumor cell Aromatic compound Tetracyclic compound Cytotoxicity Human Hydantoins Sulfur nitrogen heterocycle In vitro Cell line Quinone Structure activity relation Spiran Chemical synthesis
- Keyword (es)
- Anticanceroso Célula tumoral Compuesto aromático Compuesto tetracíclico Citotoxicidad Hombre Hidantoínas Heterociclo azufre nitrógeno In vitro Línea celular Quinona Relación estructura actividad Espirano Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16542720
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm0408565 
https://dx.doi.org/10.1021/jm0408565
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