Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo-[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors
- Author
- BORZILLERI, Robert M1 ; CAI, Zhen-Wei1 ; TOKARSKI, John4 ; VYAS, Viral3 ; WAUTLET, Barri2 ; XIOPING ZHENG1 ; BHIDE, Rajeev S1 ; ELLIS, Christopher1 ; FARGNOLI, Joseph2 ; FURA, Aberra3 ; GERHARDT, Tracy2 ; GOYAL, Bindu1 ; HUNT, John T1 ; MORTILLO, Steven2 ; LIGANG QIAN1
[1] Departments of Oncology Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, United States
[2] Departments of Oncology Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, United States
[3] Departments of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, United States
[4] Departments of Structural Biology and Modeling, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 5, pp 1429-1433, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Angiogenesis Kinase receptor SAR VEGFR-2
- Keyword (fr)
- Angiogenèse Antiangiogénique Anticancéreux Benzène dérivé Carboxamide Cellule endothéliale Composé bicyclique Facteur angiogène Facteur croissance endothélium vasculaire Homme Hétérocycle azote angulaire Hétérocycle azote In vitro Inhibiteur enzyme Inhibition Multiplication cellulaire Phénols Protein-tyrosine kinase Pyrrolidine dérivé Relation structure activité Récepteur facteur croissance Synthèse chimique Transduction signal Vaisseau sanguin Veine ombilicale Phénol dérivé Pyrrolotriazine VEGFR2 pyrrolo[2,1-f][1,2,4]triazine dérivé Enzyme Transferases
- Keyword (en)
- Angiogenesis Antiangiogenic agent Antineoplastic agent Benzene derivatives Carboxamide Endothelial cell Bicyclic compound Angiogenic factor Vascular endothelium growth factor Human Angular nitrogen heterocycle Nitrogen heterocycle In vitro Enzyme inhibitor Inhibition Cell proliferation Phenols Protein-tyrosine kinase Pyrrolidine derivatives Structure activity relation Growth factor receptor Chemical synthesis Signal transduction Blood vessel Umbilical vein Enzyme Transferases
- Keyword (es)
- Angiogénesis Antiangiogenico Anticanceroso Benceno derivado Carboxamida Célula endotelial Compuesto bicíclico Factor angiógeno Factor crecimiento endotelio vascular Hombre Heterociclo nitrógeno angular Heterociclo nitrógeno In vitro Inhibidor enzima Inhibición Multiplicación celular Fenoles Protein-tyrosine kinase Relación estructura actividad Receptor factor crecimiento Síntesis química Transducción señal Vaso sanguíneo Vena umbilical Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16558289
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.12.079 
https://dx.doi.org/10.1016/j.bmcl.2004.12.079
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