Synthesis and biological evaluation of new symmetrical derivatives as cytotoxic agents and apoptosis inducers
- Author
- SANMARTIN, Carmen1 ; ECHEVERRIA, Mikel1 ; MENDIVIL, Beatriz1 ; CORDEU, Lucia2 ; CUBEDO, Elena2 ; GARCIA-FONCILLAS, Jesus2 ; FONT, Maria3 ; PALOP, Juan Antonio1
[1] Sección de Síntesis, Departamento de Quimica Orgânica y Farmacéutica, Universidad de Navarra, Irunlarrea, 1, 31008 Pamplona, Spain
[2] Laboratorio de Bioternología y Genómica, Área de Terapia Celulur, Clínica Universitaria de Navarra, Pamplona, Spain
[3] Sección de Modelización Molecular, Departamento de Quimica Orgânica y Farmacéutica, Universidad de Navarra, Pamplona, Spain - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 6, pp 2031-2044, 14 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Amides and amines Apoptosis Carbamates: Ureas Caspase-3 Cytotoxics Symmetrical ethers
- Keyword (fr)
- Activité biologique Amide Amine Anticancéreux Apoptose Biphényle dérivé Carbamate organique Caspase Cellule tumorale Cytotoxicité Côlon DNA Ether Homme In vitro Isozyme Lignée cellulaire Lymphocyte T Modulation Mécanisme action Naphtalène dérivé Relation dose réponse Synthèse chimique Urées Vessie urinaire Caspase 3 Lignée HT29 Lignée T24 Pyrido[2,3-d]pyrimidine dérivé Pyridopyrimidine Enzyme Hydrolases Peptidases
- Keyword (en)
- Biological activity Amides Amine Antineoplastic agent Apoptosis Biphenyl derivatives Organic carbamate Caspase Tumor cell Cytotoxicity Colon DNA Ether Human In vitro Isozyme Cell line T-Lymphocyte Modulation Mechanism of action Naphthalene derivatives Dose activity relation Chemical synthesis Ureas Urinary bladder Enzyme Hydrolases Peptidases
- Keyword (es)
- Actividad biológica Amina Anticanceroso Apoptosis Bifenilo derivado Carbamato orgánico Caspase Célula tumoral Citotoxicidad Colón DNA Eter Hombre In vitro Isozima Línea celular Linfocito T Modulación Mecanismo acción Naftaleno derivado Relación dosis respuesta Síntesis química Ureas Vejiga Enzima Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16568002
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2005.01.008 
https://dx.doi.org/10.1016/j.bmc.2005.01.008
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