Synthesis of brequinar analogue inhibitors of malaria parasite dihydroorotate dehydrogenase
- Author
- BOA, Andrew N1 ; CANAVAN, Shane P1 ; HIRST, Paul R1 ; RAMSEY, Christopher2 ; STEAD, Andrew M. W2 ; MCCONKEY, Glenn A2
[1] Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, United Kingdom
[2] School of Biology, University of Leeds, Clarendon Way, Leeds LS2 9JT, United Kingdom - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 6, pp 1945-1967, 23 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide carboxylique Antipaludique Antiparasitaire Antiprotozoaire Bréquinar Dihydroorotate dehydrogenase In vitro Inhibiteur enzyme Plasmodium falciparum Quinoléine dérivé Relation structure activité Synthèse chimique Pyrrolo[3,4-c]quinoléin-1-one(2-éthyl-4-phényl) Pyrrolo[3,4-c]quinoléine dérivé Pyrroloquinoléine Quinoléine-4-carboxamide(6-[2-diéthylamino-1-hydroxyéthyl]-N,N-diisopropyl-2-phényl) Apicomplexa Enzyme Oxidoreductases Protozoa
- Keyword (en)
- Carboxylic acid Antimalarial Parasiticide Antiprotozoal agent Brequinar Dihydroorotate dehydrogenase In vitro Enzyme inhibitor Plasmodium falciparum Quinoline derivatives Structure activity relation Chemical synthesis Apicomplexa Enzyme Oxidoreductases Protozoa
- Keyword (es)
- Acido carboxílico Antipalúdico Antiparasitario Antiprotozoario Brequinar Dihydroorotate dehydrogenase In vitro Inhibidor enzima Plasmodium falciparum Quinolina derivado Relación estructura actividad Síntesis química Apicomplexa Enzima Oxidoreductases Protozoa
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16569495
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2005.01.017 
https://dx.doi.org/10.1016/j.bmc.2005.01.017
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