Synthesis and biological evaluation of new GABA-uptake inhibitors derived from proline and from pyrrolidine-2-acetic acid
- Author
- XUEQING ZHAO1 ; HOESL, Cornelia E1 ; HOEFNER, Georg C1 ; WANNER, Klaus T1
[1] Department für Pharmazie-Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich, Germany - Source
European journal of medicinal chemistry. 2005, Vol 40, Num 3, pp 231-247, 17 p ; ref : 26 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Antiepileptic GABA-uptake inhibitors GAT-1 GAT-3 Pyrrolidines
- Keyword (fr)
- Activité biologique Acétique acide Animal Anticonvulsivant Captation Configuration géométrique GABA In vitro Inhibiteur Proline Protéine transport Pyrrolidine dérivé Synthèse chimique Système nerveux central Pyrrolidine-2-acétique acide dérivé Pyrrolidine-2-carboxylique acide(1-[4,4-diphénylbut-3-ényl]-4-hydroxy) Pyrrolidine-2-carboxylique acide(4-hydroxy-1-[4,4p,4s-triméthoxytrityloxy)
- Keyword (en)
- Biological activity Acetic acid Animal Anticonvulsant Uptake Geometrical configuration GABA In vitro Inhibitor Proline Carrier protein Pyrrolidine derivatives Chemical synthesis Central nervous system
- Keyword (es)
- Actividad biológica Acético ácido Animal Anticonvulsivante Captación Configuración geométrica GABA In vitro Inhibidor Prolina Proteína transportador Síntesis química Sistema nervioso central
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B06 Anticonvulsants. Antiepileptics. Antiparkinson agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09D Gabaergic and benzodiazepinic system
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16582557
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2004.11.004 
https://dx.doi.org/10.1016/j.ejmech.2004.11.004
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