QSAR for anti-RNA-virus activity, synthesis, and assay of anti-RSV carbonucleosides given a unified representation of spectral moments, quadratic, and topologic indices
- Author
- GONZALEZ-DIAZ, Humberto1 ; CRUZ-MONTEAGUDO, Maykel2 ; VINA, Dolores1 ; SANTANA, Lourdes1 ; URIARTE, Eugenio1 ; DE CLERCQ, Erik3
[1] Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Spain
[2] Applied Chemistry Research Centre, Central University of Las Villas, 54830, Cuba
[3] Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000 Leuven, Belgium - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 6, pp 1651-1657, 7 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Antiviral activity Carbonucleoside synthesis Markov models QSAR Quadratic indices Spectral moments Topologic indices
- Keyword (fr)
- Antiviral Base donnée Col utérus Cyclohexane dérivé Cytotoxicité Homme Influenzavirus Lignée HeLa Lignée cellulaire Modèle Markov Modèle moléculaire Modèle thermodynamique Modélisation Nucléoside Principe actif Prédiction Relation structure activité Synthèse chimique Virus à ARN Adénine(9-[2-hydroxyméthylcyclohexyl]) Antiinfluenza Indice topologique Purine(2-amino-6-chloro9-[2-hydroxyméthylcyclohexyl]) QSAR Orthomyxoviridae Virus
- Keyword (en)
- Antiviral Database Uterine cervix Cyclohexane derivatives Cytotoxicity Human Influenzavirus Hela cell line Cell line Markov model Molecular model Thermodynamic model Modeling Nucleoside Active ingredient Prediction Structure activity relation Chemical synthesis RNA virus Topological index Orthomyxoviridae Virus
- Keyword (es)
- Antiviral Base dato Cuello útero Ciclohexano derivado Citotoxicidad Hombre Influenzavirus Célula HeLa Línea celular Modelo Markov Modelo molecular Modelo termodinámico Modelización Nucleósido Principio activo Predicción Relación estructura actividad Síntesis química Virus con RNA Orthomyxoviridae Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16585982
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.01.047 
https://dx.doi.org/10.1016/j.bmcl.2005.01.047
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