Synthesis and evaluation of new ω-borono-α-amino acids as rat liver arginase inhibitors
- Author
- BUSNEL, Olivier1 ; CARREAUX, Francois1 ; CARBONI, Bertrand1 ; PETHE, Stephanie2 ; VADON-LE GOFF, Sandrine2 ; MANSUY, Daniel2 ; BOUCHER, Jean-Luc2
[1] Laboratoire de Synthèse et Electrosynthèse Organiques, Institut de Chimie, Université de Rennes 1, Campus de Beaulieu, 35042 Rennes, France
[2] Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR 8601 CNRS, Université René Descartes, 45 Rue des Saints Pères, 75270 Paris, France - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 7, pp 2373-2379, 7 p ; ref : 31 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Boronic acids Inhibitors Rat liver arginase α-Amino acids
- Keyword (fr)
- Affinité Aminoacide soufré Animal Arginase Boronique acide Chaîne latérale Encombrement stérique Foie In vitro Inhibiteur enzyme Rat Rigidité moléculaire Site actif Synthèse chimique α-Aminoacide Cystéine(S-[2-(dihydroxyboryl)éthyl]) Cystéine(S-[dihydroxyborylméthyl]) Phénylalanine(4-dihydroxyboryl) Bore Composé organique Enzyme Hydrolases Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Sulfur containing aminoacid Animal Arginase Boronic acids Side chain Steric hindrance Liver In vitro Enzyme inhibitor Rat Molecular rigidity Active site Chemical synthesis α-Aminoacid Boron Organic compounds Enzyme Hydrolases Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Aminoácido azufrado Animal Arginase Cadena lateral Embarazo estérico Hígado In vitro Inhibidor enzima Rata Rigidez molecular Lugar activo Síntesis química α-Aminoácido Boro Compuesto orgánico Enzima Hydrolases Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16598430
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2005.01.053 
https://dx.doi.org/10.1016/j.bmc.2005.01.053
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