Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives : Potent and selective inhibitors of aldosterone synthase
- Author
- ULMSCHNEIDER, Sarah; MÜLLER-VIEIRA, Ursula; KLEIN, Christian D; ANTES, Iris; LENGAUER, Thomas; HARTMANN, Rolf W
FR 8.2 Pharmaceutical and Medicinal Chemistry, Saarland University, P.O. Box 15 11 50, 66041 Saarbrücken, Germany
Max Planck Institute for Informatics, Stuhlsatzenhausweg 85, 66123 Saarbrücken, Germany - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 5, pp 1563-1575, 13 p ; ref : 57 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- In vitro Indane dérivé Inhibiteur enzyme Modèle moléculaire Modélisation Naphtalène dérivé Pyridine dérivé Pyrimidine dérivé Relation structure activité Steroid 11β-monooxygenase Synthèse chimique Sélectivité Indane(5-fluoro-1-[pyrimidin-5-ylméthylène) Enzyme Oxidoreductases
- Keyword (en)
- In vitro Indan derivatives Enzyme inhibitor Molecular model Modeling Naphthalene derivatives Pyridine derivatives Pyrimidine derivatives Structure activity relation Steroid 11β-monooxygenase Chemical synthesis Selectivity Enzyme Oxidoreductases
- Keyword (es)
- In vitro Inhibidor enzima Modelo molecular Modelización Naftaleno derivado Piridina derivado Pirimidina derivado Relación estructura actividad Steroid 11β-monooxygenase Síntesis química Selectividad Enzima Oxidoreductases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F09 Miscellaneous
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16599957
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm0492397 
https://dx.doi.org/10.1021/jm0492397
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