Novel and potent cyclic cyanamide-based cathepsin K inhibitors
- Author
- DEATON, David N1 ; HASSELL, Anne M2 ; MCFADYEN, Robert B1 ; MILLER, Aaron B2 ; MILLER, Larry R3 ; SHEWCHUK, Lisa M2 ; TAVARES, Francis X1 ; WILLARD, Derril H4 ; WRIGHT, Lois L5
[1] Department of Medicinal Chemistry, GlaxoSmithKline, Research Triangle Park, NC 27709, United States
[2] Discovery Research Computational, Analytical, and Structural Sciences, GlaxoSmithKline, Research Triangle Park, NC 27709, United States
[3] Department of Molecular Pharmacology, GlaxoSmithKline, Research Triangle Park, NC 27709, United States
[4] Department of Gene Expression and Protein Purification, GlaxoSmithKline, Research Triangle Park, NC 27709, United States
[5] Discovery Research Biology, GlaxoSmithKline, Research Triangle Park, NC 27709, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 7, pp 1815-1819, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Benzène dérivé Carbamate organique Carboxamide Cathepsin K Complexe enzyme inhibiteur Cyanamides Cycle 4 chaînons Cycle 5 chaînons Cycle 6 chaînons Cyclohexane dérivé Homme In vitro Inhibiteur enzyme Modèle moléculaire Modélisation Pyrrolidine dérivé Relation structure activité Site actif Synthèse chimique Azétidine-1-carbonitrile dérivé Azétidine-2-carboxylique acide(1-cyano) ester 2-cyclohexyl-1-méthyléthyle Inhibiteur cathepsin K Pipéridine-1-carbonitrile dérivé Prolinamide dérivé Proline dérivé Pyrrolidine-1-carbonitrile dérivé Cysteine endopeptidases Enzyme Hydrolases Peptidases
- Keyword (en)
- Benzene derivatives Organic carbamate Carboxamide Cathepsin K Inhibitor enzyme complex Cyanamides Four membered ring Five membered ring Six membered ring Cyclohexane derivatives Human In vitro Enzyme inhibitor Molecular model Modeling Pyrrolidine derivatives Structure activity relation Active site Chemical synthesis Cysteine endopeptidases Enzyme Hydrolases Peptidases
- Keyword (es)
- Benceno derivado Carbamato orgánico Carboxamida Cathepsin K Complejo enzima inhibidor Cianamidas Ciclo 4 eslabones Ciclo 5 eslabones Ciclo 6 eslabones Ciclohexano derivado Hombre In vitro Inhibidor enzima Modelo molecular Modelización Relación estructura actividad Lugar activo Síntesis química Cysteine endopeptidases Enzima Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16626919
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.02.033 
https://dx.doi.org/10.1016/j.bmcl.2005.02.033
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