Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists
- Author
- HONGYU ZHAO1 ; ZHILI XIN1 ; SHAM, Hing L1 ; GANG LIU1 ; PATEL, Jyoti R1 ; NELSON, Lissa T. J1 ; BO LIU1 ; SZCZEPANKIEWICZ, Bruce G1 ; SCHAEFER, Verlyn G1 ; FALLS, H. Douglas1 ; KASZUBSKA, Wiweka1 ; COLLINS, Christine A1
[1] Metabolic Disease Research, Global Pharmaceutical Research and Development, R4MC, AP-10, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 7, pp 1825-1828, 4 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Amine aromatique Aniline dérivé Animal Antagoniste Biodisponibilité Carbamate organique Carboxamide Composé aromatique Composé bicyclique In vitro In vivo Pharmacocinétique Rat Relation structure activité Récepteur biologique Récepteur hormonal STH-RH Synthèse chimique Sélectivité Voie orale Naphtalène-2-carboxamide(2-[t-butoxycarbonyl méthyl amino]-N-[4-diéthylamino-2-méthylphényl]-8-méthoxy-1,2,3,4-tétrahydro) Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Aromatic amine Aniline derivatives Animal Antagonist Bioavailability Organic carbamate Carboxamide Aromatic compound Bicyclic compound In vitro In vivo Pharmacokinetics Rat Structure activity relation Biological receptor Hormonal receptor Somatotropin releasing factor Chemical synthesis Selectivity Oral administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Amina aromática Anilina derivado Animal Antagonista Biodisponibilidad Carbamato orgánico Carboxamida Compuesto aromático Compuesto bicíclico In vitro In vivo Farmacocinética Rata Relación estructura actividad Receptor biológico Receptor hormonal STH-RH Síntesis química Selectividad Vía oral Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02O Hormones. Endocrine system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16626921
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.02.026 
https://dx.doi.org/10.1016/j.bmcl.2005.02.026
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