Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Weel
- Author
- PALMER, Brian D1 ; SMAILL, Jeff B1 ; REWCASTLE, Gordon W1 ; DOBRUSIN, Ellen M2 ; KRAKER, Alan2 ; MOORE, Charles W2 ; STEINKAMPF, Randall W2 ; DENNY, William A1
[1] Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
[2] Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48106-1047, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 7, pp 1931-1935, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide carboxylique Amine aromatique Amine tertiaire Aniline dérivé Benzène dérivé Carboxamide Ester Gène onc cellulaire In vitro Inhibiteur enzyme Inhibition Mitose Phase G2 Protein-tyrosine kinase Relation structure activité Récepteur facteur croissance Synthèse chimique Sélectivité Transduction signal Gène Wee1 Gène c src Produit gène Pyrido[2,3-d]pyrimidin-7-one(2-anilino-6-aryl-8-méthyl) Pyridopyrimidine Chlore Composé organique Enzyme Fluor Composé organique Transferases
- Keyword (en)
- Carboxylic acid Aromatic amine Tertiary amine Aniline derivatives Benzene derivatives Carboxamide Ester C-Onc gene In vitro Enzyme inhibitor Inhibition Mitosis G2 Phase Protein-tyrosine kinase Structure activity relation Growth factor receptor Chemical synthesis Selectivity Signal transduction Chlorine Organic compounds Enzyme Fluorine Organic compounds Transferases
- Keyword (es)
- Acido carboxílico Amina aromática Amina terciaria Anilina derivado Benceno derivado Carboxamida Ester Gen onc celular In vitro Inhibidor enzima Inhibición Mitosis Fase G2 Protein-tyrosine kinase Relación estructura actividad Receptor factor crecimiento Síntesis química Selectividad Transducción señal Cloro Compuesto orgánico Enzima Fluor Compuesto orgánico Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16626942
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.01.079 
https://dx.doi.org/10.1016/j.bmcl.2005.01.079
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