Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines
- Author
- JANSSENS, Frans; LEENAERTS, Jos; DIELS, Gaston; DE BOECK, Benoit; MEGENS, Anton; LANGLOIS, Xavier1 ; VAN ROSSEM, Koen2 ; BEETENS, Johan2 ; BORGERS, Marcel2
[1] CNS-Psychiatry 1 Department, Johnson & Johnson Pharmaceutical Research & Development, a division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium
[2] Barrier Therapeutics, Cipalstraat 3, 2440 Geel, Belgium - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 6, pp 2154-2166, 13 p ; ref : 29 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Allergie Animal Antagoniste Antiallergique Antihistaminique Chien Chimiothérapie Cobaye Composé aromatique Composé tétracyclique Homme Hétérocycle azote angulaire In vitro In vivo Pathologie expérimentale Peau pathologie Rat Relation structure activité Récepteur histaminergique H1 Spirane Synthèse chimique Sélectivité Traitement Voie orale Voie souscutanée Spiro[imidazo[2,1-b][3]benzoazépine-11:4p-pipéridine]-2-carboxamide(5,6-dihydro) chlorhydrate Carnivora Fissipedia Immunopathologie Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Allergy Animal Antagonist Antiallergic Antihistaminic Dog Chemotherapy Guinea pig Aromatic compound Tetracyclic compound Human Angular nitrogen heterocycle In vitro In vivo Experimental disease Skin disease Rat Structure activity relation H1 Histamine receptor Spiran Chemical synthesis Selectivity Treatment Oral administration Subcutaneous administration Carnivora Fissipedia Immunopathology Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Alergia Animal Antagonista Antialérgico Antihistamínico Perro Quimioterapia Cobayo Compuesto aromático Compuesto tetracíclico Hombre Heterociclo nitrógeno angular In vitro In vivo Patología experimental Piel patología Rata Relación estructura actividad Receptor histaminérgico H1 Espirano Síntesis química Selectividad Tratamiento Vía oral Vía subcutánea Carnivora Fissipedia Inmunopatología Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02J Histamine and antagonists. Allergy
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16655418
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm049495j 
https://dx.doi.org/10.1021/jm049495j
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