QSAR by LFER model of cytotoxicity data of anti-HIV 5-phenyl-1-phenylamino-1H-imidazole derivatives using principal component factor analysis and genetic function approximation
- Author
- ROY, Kunal1 ; LEONARD, J. Thomas1
[1] Drug Theoretics and Cheminformatics Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 8, pp 2967-2973, 7 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- 5-Phenyl-1-phenylamino-1H-imidazole Anti-HIV activity Cytotoxicity Hansch analysis LFER QSAR
- Keyword (fr)
- Algorithme génétique Analyse factorielle Antiviral Cytotoxicité Energie libre Imidazole dérivé Liaison hydrogène Lipophilie Modèle Propriété thermodynamique Prédiction Relation structure activité Réfractivité Régression linéaire Régression multiple Thiol Virus immunodéficience humaine Anti hiv Imidazole(1-[chloroanilino]-2-mercapto-4-méthyl-5-phényl) QSAR Lentivirus Retroviridae Virus
- Keyword (en)
- Genetic algorithm Factor analysis Antiviral Cytotoxicity Free energy Imidazole derivatives Hydrogen bond Lipophilicity Models Thermodynamic properties Prediction Structure activity relation Refractivity Linear regression Multiple regression Thiol Human immunodeficiency virus Lentivirus Retroviridae Virus
- Keyword (es)
- Algoritmo genético Análisis factorial Antiviral Citotoxicidad Energía libre Imidazol derivado Enlace hidrógeno Lipofilia Modelo Propiedad termodinámica Predicción Relación estructura actividad Refractividad Regresión lineal Regresión múltiple Tiol Human immunodeficiency virus Lentivirus Retroviridae Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16661482
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2005.02.003 
https://dx.doi.org/10.1016/j.bmc.2005.02.003
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