Synthesis and biological evaluation of S-[11C]methylated mercaptoimidazole piperazinyl derivatives as potential radioligands for imaging 5-HT1A receptors by positron emission tomography (PET)
- Author
- GARCIA, Raquel1 ; XAVIER, Catarina1 ; PAULO, Antonio1 ; SANTOS, Isabel1 ; KNIESS, Torsten2 ; BERGMANN, R2 ; WÜST, Frank2
[1] Departamento de Química, ITN, Estrada Nacional 10, 2686-953 Sacavém, Portugal
[2] Institut of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf, PF 51 01 19, 01314 Dresden, Germany - Source
Journal of labelled compounds & radiopharmaceuticals. 2005, Vol 48, Num 4, pp 301-315, 15 p ; ref : 30 ref
- ISSN
- 0362-4803
- Scientific domain
- Biochemistry, molecular biology, biophysics; Organic chemistry; Pharmacology drugs
- Publisher
- Wiley, Chichester
/
Wiley, New York, NY
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- 5-HT1A receptors carbon-11 mercaptoimidazoles piperazines positron emission tomography
- Keyword (fr)
- Activité biologique Agent scintigraphique Animal Carbone 11 Carbone Isotope Carboxamide Distribution Encéphale Imidazole dérivé Ligand Marquage radioisotopique Méthylation Pharmacocinétique Pipérazine dérivé Rat Récepteur sérotoninergique 5-HT1A Synthèse chimique Système nerveux central Tomographie émission positon Pipérazine(1-[2-méthoxyphényl]-4-[4-(1-méthyl-2-méthylthioimidazole-5-carbonyl méthyl amino)butyl]) Pipérazine(1-[2-méthoxyphényl]-4-[4-(2-méthylthioimidazol-1-yl)butyl]) Radioligand Mammalia Rodentia Vertebrata
- Keyword (en)
- Biological activity Scintigraphic agent Animal Carbon 11 Carbon Isotopes Carboxamide Distribution Encephalon Imidazole derivatives Ligand Radiolabelling Methylation Pharmacokinetics Piperazine derivatives Rat 5-HT1A Serotonine receptor Chemical synthesis Central nervous system Positron emission tomography Mammalia Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Agente centelleográfico Animal Carbono Isótopo Carboxamida Distribución Encéfalo Imidazol derivado Ligando Marcación radioisotópica Metilación Farmacocinética Piperazina derivado Rata Receptor serotoninérgico 5-HT1A Síntesis química Sistema nervioso central Tomografía emisión positrones Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09C Serotoninergic system
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02T Contrast media. Radiopharmaceuticals
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16661751
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/jlcr.924 
https://dx.doi.org/10.1002/jlcr.924
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