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Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin

Author
MCGUIGAN, Christopher1 ; THIERY, Jean-Christophe1 ; DAVERIO, Felice1 ; JIANG, Wen G2 ; DAVIES, Gaynor2 ; MASON, Malcolm2 3
[1] Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, United Kingdom
[2] Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
[3] Velindre Hospital, Cardiff University, Velindre Road, Cardiff CF14 2TL, United Kingdom
Source

Bioorganic & medicinal chemistry. 2005, Vol 13, Num 9, pp 3219-3227, 9 p

ISSN
0968-0896
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier Science, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
Anti-cancer Nucleosides Nucleotides Phosphoramidates ProTides Thymectacin
Keyword (fr)
Activité biologique Aminoester Anticancéreux Biphényle dérivé Brivudine Cancer côlon Cancer prostate Cellule tumorale Composé benzylique Côlon Désoxyribonucléotide In vitro Lignée cellulaire Nucléotide Phosphoramidate organique Phosphore Composé organique Promédicament Pyrimidine nucléotide Synthèse chimique Lignée HT115 Appareil digestif pathologie Appareil génital mâle pathologie Appareil urinaire pathologie Désoxyribonucléoside Intestin pathologie Prostate pathologie Pyrimidine nucléoside Tumeur maligne
Keyword (en)
Biological activity Aminoester Antineoplastic agent Biphenyl derivatives Brivudine Colon cancer Prostate cancer Tumor cell Benzylic compound Colon Deoxyribonucleotide In vitro Cell line Nucleotide Organic amidophosphate Phosphorus Organic compounds Prodrug Pyrimidine nucleotide Chemical synthesis Digestive diseases Male genital diseases Urinary system disease Deoxyribonucleoside Intestinal disease Prostate disease Pyrimidine nucleoside Malignant tumor
Keyword (es)
Actividad biológica Aminoester Anticanceroso Bifenilo derivado Brivudina Cáncer del colon Cáncer de la próstata Célula tumoral Compuesto benzílico Colón Desoxirribonucleótido In vitro Línea celular Nucleótido Fosforamidato orgánico Fósforo Compuesto orgánico Promedicamento Pirimidina nucleótido Síntesis química Aparato digestivo patología Aparato genital macho patología Aparato urinario patología Desoxirribonucleósido Intestino patología Prostata patología Pirimidina nucleósido Tumor maligno
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
16678699

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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