No auxiliary, No byproduct strategy for water-soluble prodrugs of taxoids : Scope and limitation of O-N intramolecular acyl and acyloxy migration reactions
- Author
- SKWARCZYNSKI, Mariusz1 ; SOHMA, Youhei1 ; NOGUCHI, Mayo1 ; KIMURA, Maiko1 ; HAYASHI, Yoshio1 ; HAMADA, Yoshio1 ; KIMURA, Tooru1 ; KISO, Yoshiaki1
[1] Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 7, pp 2655-2666, 12 p ; ref : 60 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Composé hydrosoluble Diterpène Hydrosolubilité Promédicament Propriété physicochimique Réaction intramoléculaire Synthèse chimique Taxane dérivé Terpénoïde Transposition chimique Taxol dérivé Taxol(2'-O-acyl) Taxoïde
- Keyword (en)
- Antineoplastic agent Water soluble compound Diterpene Water solubility Prodrug Physicochemical properties Intramolecular reaction Chemical synthesis Taxane derivatives Terpenoid Chemical rearrangement
- Keyword (es)
- Anticanceroso Compuesto hidrosoluble Diterpeno Hidrosolubilidad Promedicamento Propiedad fisicoquímica Reacción intramolecular Síntesis química Taxane derivado Terpenoide Transposición química
- Classification
- Pascal
- 001 Exact sciences and technology / 001C Chemistry / 001C03 Organic chemistry / 001C03C Preparations and properties / 001C03C05 Alicyclic compounds, terpenoids, prostaglandins, steroids / 001C03C05B Terpenoids
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Organic chemistry Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16680612
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm049344g 
https://dx.doi.org/10.1021/jm049344g
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