Synthesis of 2',3'-dideoxynucleoside 5' -α -P -borano-β,γ-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase
- Author
- BOYLE, Nicholas A1 ; RAJWANSHI, Vivek K1 ; BRUICE, Thomas W1 ; DAN COOK, P1 ; PRHAVC, Marija1 ; GUANGYI WANG1 ; FAGAN, Patrick1 ; FU CHEN1 ; EWING, Gregory J1 ; BROOKS, Jennifer L1 ; HURD, Tiffany1 ; LEEDS, Janet M1
[1] Research Laboratories, Biota, Inc., 2232 Rutherford Road, Carlsbad, California 92008, United States - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 7, pp 2695-2700, 6 p ; ref : 21 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antiviral Didésoxynucléoside Inhibiteur enzyme Phosphine-borane Phosphore composé RNA-directed DNA polymerase Relation structure activité Résistance hydrolyse Synthèse chimique Triphosphate Virus HIV1 Zidovudine Analogue nucléoside Bore Composé Enzyme Fluor Composé organique Lentivirus Nucleotidyltransferases Pyrimidine nucléoside Retroviridae Transferases Virus immunodéficience humaine Virus
- Keyword (en)
- Antiviral Dideoxynucleoside Enzyme inhibitor Phosphine borane Phosphorus compound RNA-directed DNA polymerase Structure activity relation Hydrolysis resistance Chemical synthesis Triphosphates HIV-1 virus Zidovudine Nucleoside analog Boron Compounds Enzyme Fluorine Organic compounds Lentivirus Nucleotidyltransferases Pyrimidine nucleoside Retroviridae Transferases Human immunodeficiency virus Virus
- Keyword (es)
- Antiviral Didesoxinucleósido Inhibidor enzima Fosfina-borano Fósforo compuesto RNA-directed DNA polymerase Relación estructura actividad Resistencia hidrólisis Síntesis química Trifosfato HIV-1 virus Zidovudina Análogo nucleósido Boro Compuesto Enzima Fluor Compuesto orgánico Lentivirus Nucleotidyltransferases Pirimidina nucleósido Retroviridae Transferases Human immunodeficiency virus Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16680616
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1021/jm040101y 
https://dx.doi.org/10.1021/jm040101y
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm040101y\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:145:\"Synthesis of 2',3'-dideoxynucleoside 5' -\u03b1 -P -borano-\u03b2,\u03b3-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"48\";s:8:\"\u0000*\u0000issue\";s:1:\"7\";s:8:\"\u0000*\u0000spage\";s:4:\"2695\";s:8:\"\u0000*\u0000epage\";s:4:\"2700\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:5:\"BOYLE\";s:10:\"\u0000*\u0000aufirst\";s:10:\"Nicholas A\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:11:{i:0;s:18:\"RAJWANSHI, Vivek K\";i:1;s:16:\"BRUICE, Thomas W\";i:2;s:11:\"DAN COOK, P\";i:3;s:14:\"PRHAVC, Marija\";i:4;s:12:\"GUANGYI WANG\";i:5;s:14:\"FAGAN, Patrick\";i:6;s:7:\"FU CHEN\";i:7;s:16:\"EWING, Gregory J\";i:8;s:18:\"BROOKS, Jennifer L\";i:9;s:13:\"HURD, Tiffany\";i:10;s:14:\"LEEDS, Janet M\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:145:\"Synthesis of 2',3'-dideoxynucleoside 5' -\u03b1 -P -borano-\u03b2,\u03b3-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"6\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm040101y\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:145:\"Synthesis of 2',3'-dideoxynucleoside 5' -\u03b1 -P -borano-\u03b2,\u03b3-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"48\";s:8:\"\u0000*\u0000issue\";s:1:\"7\";s:8:\"\u0000*\u0000spage\";s:4:\"2695\";s:8:\"\u0000*\u0000epage\";s:4:\"2700\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:5:\"BOYLE\";s:10:\"\u0000*\u0000aufirst\";s:10:\"Nicholas A\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:11:{i:0;s:18:\"RAJWANSHI, Vivek K\";i:1;s:16:\"BRUICE, Thomas W\";i:2;s:11:\"DAN COOK, P\";i:3;s:14:\"PRHAVC, Marija\";i:4;s:12:\"GUANGYI WANG\";i:5;s:14:\"FAGAN, Patrick\";i:6;s:7:\"FU CHEN\";i:7;s:16:\"EWING, Gregory J\";i:8;s:18:\"BROOKS, Jennifer L\";i:9;s:13:\"HURD, Tiffany\";i:10;s:14:\"LEEDS, Janet M\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:145:\"Synthesis of 2',3'-dideoxynucleoside 5' -\u03b1 -P -borano-\u03b2,\u03b3-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"6\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm040101y\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm040101y\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:145:\"Synthesis of 2',3'-dideoxynucleoside 5' -\u03b1 -P -borano-\u03b2,\u03b3-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"48\";s:8:\"\u0000*\u0000issue\";s:1:\"7\";s:8:\"\u0000*\u0000spage\";s:4:\"2695\";s:8:\"\u0000*\u0000epage\";s:4:\"2700\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:5:\"BOYLE\";s:10:\"\u0000*\u0000aufirst\";s:10:\"Nicholas A\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:11:{i:0;s:18:\"RAJWANSHI, Vivek K\";i:1;s:16:\"BRUICE, Thomas W\";i:2;s:11:\"DAN COOK, P\";i:3;s:14:\"PRHAVC, Marija\";i:4;s:12:\"GUANGYI WANG\";i:5;s:14:\"FAGAN, Patrick\";i:6;s:7:\"FU CHEN\";i:7;s:16:\"EWING, Gregory J\";i:8;s:18:\"BROOKS, Jennifer L\";i:9;s:13:\"HURD, Tiffany\";i:10;s:14:\"LEEDS, Janet M\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:145:\"Synthesis of 2',3'-dideoxynucleoside 5' -\u03b1 -P -borano-\u03b2,\u03b3-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"6\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm040101y\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:145:\"Synthesis of 2',3'-dideoxynucleoside 5' -\u03b1 -P -borano-\u03b2,\u03b3-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"48\";s:8:\"\u0000*\u0000issue\";s:1:\"7\";s:8:\"\u0000*\u0000spage\";s:4:\"2695\";s:8:\"\u0000*\u0000epage\";s:4:\"2700\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:5:\"BOYLE\";s:10:\"\u0000*\u0000aufirst\";s:10:\"Nicholas A\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:11:{i:0;s:18:\"RAJWANSHI, Vivek K\";i:1;s:16:\"BRUICE, Thomas W\";i:2;s:11:\"DAN COOK, P\";i:3;s:14:\"PRHAVC, Marija\";i:4;s:12:\"GUANGYI WANG\";i:5;s:14:\"FAGAN, Patrick\";i:6;s:7:\"FU CHEN\";i:7;s:16:\"EWING, Gregory J\";i:8;s:18:\"BROOKS, Jennifer L\";i:9;s:13:\"HURD, Tiffany\";i:10;s:14:\"LEEDS, Janet M\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:145:\"Synthesis of 2',3'-dideoxynucleoside 5' -\u03b1 -P -borano-\u03b2,\u03b3-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"6\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm040101y\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:145:\"Synthesis of 2',3'-dideoxynucleoside 5' -\u03b1 -P -borano-\u03b2,\u03b3-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"48\";s:8:\"\u0000*\u0000issue\";s:1:\"7\";s:8:\"\u0000*\u0000spage\";s:4:\"2695\";s:8:\"\u0000*\u0000epage\";s:4:\"2700\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:5:\"BOYLE\";s:10:\"\u0000*\u0000aufirst\";s:10:\"Nicholas A\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:11:{i:0;s:18:\"RAJWANSHI, Vivek K\";i:1;s:16:\"BRUICE, Thomas W\";i:2;s:11:\"DAN COOK, P\";i:3;s:14:\"PRHAVC, Marija\";i:4;s:12:\"GUANGYI WANG\";i:5;s:14:\"FAGAN, Patrick\";i:6;s:7:\"FU CHEN\";i:7;s:16:\"EWING, Gregory J\";i:8;s:18:\"BROOKS, Jennifer L\";i:9;s:13:\"HURD, Tiffany\";i:10;s:14:\"LEEDS, Janet M\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:145:\"Synthesis of 2',3'-dideoxynucleoside 5' -\u03b1 -P -borano-\u03b2,\u03b3-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"6\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
