Structure-based optimization of a non-β-lactam lead results in inhibitors that do not up-regulate β-lactamase expression in cell culture
- Author
- TONDI, Donatella; MORANDI, Federica; BONNET, Richard1 ; COSTI, M. Paola; SHOICHET, Brian K
Department of Pharmaceutical Chemistry, University of California- San Francisco, 600 16th Street, San Francisco, California 94143-2240, United States
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Modena e Reggio Emilia, Via Campi 183, 41100, Modena, Italy
[1] Service de Bactériologie, Faculté de Médecine, Université d'Auvergne, 63001 Clermont-Ferrand, France - Source
Journal of the American Chemical Society. 2005, Vol 127, Num 13, pp 4632-4639, 8 p ; ref : 35 ref
- CODEN
- JACSAT
- ISSN
- 0002-7863
- Scientific domain
- Biochemistry, molecular biology, biophysics; Chemistry; Organic chemistry; Atomic molecular physics
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Analyse biochimique Analyse structurale Cycle 5 chaînons Hétérocycle soufre Inhibiteur enzyme Relation structure activité Relation structure fonction Thiophène dérivé β-Lactamase Thiophène-2-carboxylique acide(3-[4-chlorophényl]sulfamoyl) Enzyme Hydrolases
- Keyword (en)
- Biological activity Biochemical analysis Structural analysis Five membered ring Sulfur heterocycle Enzyme inhibitor Structure activity relation Structure function relationship Thiophene derivatives β-Lactamase Enzyme Hydrolases
- Keyword (es)
- Actividad biológica Análisis bioquímico Análisis estructural Ciclo 5 eslabones Heterociclo azufre Inhibidor enzima Relación estructura actividad Relación estructura función Tiofeno derivado β-Lactamase Enzima Hydrolases
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry / 002A02E Enzymes and enzyme inhibitors / 002A02E04 Hydrolases
- Discipline
- Analytical, structural and metabolic biochemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16698517
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/ja042984o 
https://dx.doi.org/10.1021/ja042984o
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