Synthesis, molecular structure, and in vitro antitumor activity of new 4-chloro-2-mercaptobenzenesulfonamide derivatives
- Author
- SLAWINSKI, Jaroslaw1 ; GDANIEC, Maria2
[1] Department of Chemical Technology of Drugs, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland
[2] Faculty of Chemistry, A. Mickiewicz University, 60-780 Pozna, Poland - Source
European journal of medicinal chemistry. 2005, Vol 40, Num 4, pp 377-389, 13 p ; ref : 37 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- 4-Chloro-2-mercapto-N-(1,2,4-triazin-3-yl)benzenesulfonamide Antitumor effect Crystal structures Synthesis
- Keyword (fr)
- Anticancéreux Benzène dérivé Carboxamide Carcinome non petite cellule bronchopulmonaire Cellule tumorale Composé bicyclique Cycle 6 chaînons Cytotoxicité Diffraction RX Hétérocycle azote In vitro Lignée cellulaire Relation structure activité Structure cristalline Structure moléculaire Sulfure organique Synthèse chimique Sélectivité 1,2,4-Triazine dérivé 2,3,5-Triazabicyclo[4.2.0]octatétraène dérivé Benzamide5-[(3-[(1-acétyléthylidène)amino]guanidino)sulfonyl]-4-benzylthio-2-chloro-N-phényl Benzènesulfonamide dérivé Lignée HOP62 Chlore Composé organique
- Keyword (en)
- Antineoplastic agent Benzene derivatives Carboxamide non-small cell lung carcinoma Tumor cell Bicyclic compound Six membered ring Cytotoxicity X ray diffraction Nitrogen heterocycle In vitro Cell line Structure activity relation Crystalline structure Molecular structure Organic sulfide Chemical synthesis Selectivity Chlorine Organic compounds
- Keyword (es)
- Anticanceroso Benceno derivado Carboxamida Carcinoma no pequeňa célula bronchopulmonar Célula tumoral Compuesto bicíclico Ciclo 6 eslabones Citotoxicidad Difracción RX Heterociclo nitrógeno In vitro Línea celular Relación estructura actividad Estructura cristalina Estructura molecular Sulfuro orgánico Síntesis química Selectividad Cloro Compuesto orgánico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16706137
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2004.11.014 
https://dx.doi.org/10.1016/j.ejmech.2004.11.014
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