Novel and potent 17β-hydroxy steroid dehydrogenase type 1 inhibitors
- Author
- LAWRENCE, Harshani R1 ; VICKER, Nigel1 ; ALLAN, Gillian M1 ; SMITH, Andrew1 ; MAHON, Mary F1 2 ; TUTILL, Helena J3 ; PUROHIT, Atul3 ; REED, Michael J3 ; POTTER, Barry V. L1
[1] Medicinal Chemistry, Department of Pharmacy and Pharmacology and Sterix Ltd., University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom
[2] Department of Chemistry, University of Bath, Claverton Down, Bath, BA2 7AY, United Kingdom
[3] Endocrinology and Metabolic Medicine and Sterix Ltd., Faculty of Medicine, Imperial College London, St. Mary's Hospital, London, W2 1NY, United Kingdom - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 8, pp 2759-2762, 4 p ; ref : 23 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- 3(or 17)β-Hydroxysteroid dehydrogenase Anticancéreux Carboxamide Cellule tumorale Complexe enzyme inhibiteur Cétoamide Glande mammaire Homme Hétérocycle azote In vitro Inhibiteur enzyme Lignée cellulaire Modèle moléculaire Modélisation Oestrogène Phénols Pyridine dérivé Relation structure activité Stéroïde Synthèse chimique Sélectivité Lignée MDAMB231 Lignée T47D Oestra-1,3,5(10)-triéne-16-acétamide(2-éthyl-3-hydroxy-17-oxo-N-[3-picolyl]) Enzyme Oxidoreductases
- Keyword (en)
- 3(or 17)β-Hydroxysteroid dehydrogenase Antineoplastic agent Carboxamide Tumor cell Inhibitor enzyme complex Ketoamide Mammary gland Human Nitrogen heterocycle In vitro Enzyme inhibitor Cell line Molecular model Modeling Estrogen Phenols Pyridine derivatives Structure activity relation Steroid Chemical synthesis Selectivity Enzyme Oxidoreductases
- Keyword (es)
- 3(or 17)β-Hydroxysteroid dehydrogenase Anticanceroso Carboxamida Célula tumoral Complejo enzima inhibidor Cetoamida Glándula mamaria Hombre Heterociclo nitrógeno In vitro Inhibidor enzima Línea celular Modelo molecular Modelización Estrógeno Fenoles Piridina derivado Relación estructura actividad Esteroide Síntesis química Selectividad Enzima Oxidoreductases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16740233
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm049045r 
https://dx.doi.org/10.1021/jm049045r
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