Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens : Synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model
- Author
- HANDRATTA, Venkatesh D; VASAITIS, Tadas S; BRODIE, Angela M. H; NJAR, Vincent C. O; GEDIYA, Lalji K; KATARIA, Ritesh; CHOPRA, Pankaj; NEWMAN, Donnell; FARQUHAR, Rena; ZHIYONG GUO; YUN QIU
- Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 8, pp 2972-2984, 13 p ; ref : 35 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Androstane dérivé Animal Antiandrogène Anticancéreux Antihormone Benzimidazole dérivé Benzotriazole dérivé Cancer prostate Chimiothérapie Cytochrome P450 Drug-metabolizing enzyme Homme Hétérocycle azote Inhibiteur enzyme Isozyme Pharmacocinétique Pyrazine dérivé Pyrimidine dérivé Relation structure activité Steroid 17α-monooxygenase Stéroïde Synthèse chimique Traitement Unspecific monooxygenase Voie souscutanée Androsta-5,16-dién-3β-ol dérivé Cytochrome CYP17 Appareil génital mâle pathologie Appareil urinaire pathologie Enzyme Oxidoreductases
- Keyword (en)
- Androstane derivatives Animal Antiandrogen Antineoplastic agent Antihormone Benzimidazole derivatives Benzotriazole derivatives Prostate cancer Chemotherapy Cytochrome P450 Drug-metabolizing enzyme Human Nitrogen heterocycle Enzyme inhibitor Isozyme Pharmacokinetics Pyrazine derivatives Pyrimidine derivatives Structure activity relation Steroid 17α-monooxygenase Steroid Chemical synthesis Treatment Unspecific monooxygenase Subcutaneous administration Male genital diseases Urinary system disease Enzyme Oxidoreductases
- Keyword (es)
- Androstano derivado Animal Antiandrógeno Anticanceroso Antihormona Benzimidazol derivado Benzotriazol derivado Cáncer de la próstata Quimioterapia Citocromo P450 Drug-metabolizing enzyme Hombre Heterociclo nitrógeno Inhibidor enzima Isozima Farmacocinética Pirazina derivado Pirimidina derivado Relación estructura actividad Steroid 17α-monooxygenase Esteroide Síntesis química Tratamiento Unspecific monooxygenase Vía subcutánea Aparato genital macho patología Aparato urinario patología Enzima Oxidoreductases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16740257
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm040202w 
https://dx.doi.org/10.1021/jm040202w
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