Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases
- Author
- KIM, Jin-Wook1 2 3 ; KIM, Yong-Woo4 ; INAGAKI, Yuichi2 ; HWANG, You-A1 ; MITSUTAKE, Susumu2 ; RYU, Yeon-Woo3 ; WON KOO LEE4 ; HA, Hyun-Joon5 ; PARK, Chang-Seo1 ; IGARASHI, Yasuyuki2
[1] Doosan Biotech, 39-3, Seongbok-dong, Yongin-si, Gyeonggi-do 449-795, Korea, Republic of
[2] Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Science, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo 060-0812, Japan
[3] Department of Molecular Science and Technology, Ajou University, San 5, Wonchun-dong, Yeongtong-gu, Suwon 443-749, Korea, Republic of
[4] Department of Chemistry, Program of Integrated Biotechnology, Sogang University, Sinsu-dong, Mapo-ku, Seoul 121-742, Korea, Republic of
[5] Department of Chemistry, Hankuk University of Foreign Studies, 89 Wangsan-ri Mohyun, Yongin-si, Kyounggi-do 449-791, Korea, Republic of - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 10, pp 3475-3485, 11 p ; ref : 50 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Aziridine Inhibitor Sphingosine analog Sphingosine kinase
- Keyword (fr)
- Amide gras Benzène dérivé Céramide Expression génique Hamster Homme In vitro Inhibiteur enzyme Kinase Lignée CHO Lignée cellulaire Ovaire Protein kinase C Relation structure activité Sphingosine Synthèse chimique Sélectivité Thrombocyte Transduction signal Butane-1,3-diol(2-amino-3-[4-octylphényl]) Sphingosine kinase Stéaramide(N-[2-hydroxy-3-phényl-1-(pyrrolidinométhyl)propyl]) Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Fatty amide Benzene derivatives Ceramide Gene expression Hamster Human In vitro Enzyme inhibitor Kinase CHO cell line Cell line Ovary Protein kinase C Structure activity relation Sphingosin Chemical synthesis Selectivity Platelet Signal transduction Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Amida grasa Benceno derivado Cerámida Expresión genética Hamster Hombre In vitro Inhibidor enzima Kinase Célula CHO Línea celular Ovario Protein kinase C Relación estructura actividad Esfingosina Síntesis química Selectividad Trombocito Transducción señal Enzima Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16742160
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2005.02.053 
https://dx.doi.org/10.1016/j.bmc.2005.02.053
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