Structure-based design of protein tyrosine phosphatase-1B inhibitors
- Author
- BLACK, Emma1 ; BREED, Jason1 ; PANNIFER, Andrew D3 ; READ, Jon1 ; REES, Amanda1 ; RUSSELL, Daniel J2 ; TOADER, Dorin2 ; TUCKER, Julie1 ; BREEZE, Alexander L1 ; EMBREY, Kevin1 ; GARCIA, Robert1 ; GERO, Thomas W2 ; GODFREY, Linda1 ; KENNY, Peter W1 ; MORLEY, Andrew D1 ; MINSHULL, Claire A1
[1] AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom
[2] AstraZeneca, 35 Gatehouse Drive, Walthum, MA 0245102451, United States
[3] Pfizer Central Research, Sandwich, Kent CT13 9NJ, United Kingdom - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 10, pp 2503-2507, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Protein tyrosine phosphatase-1B Structure-based design
- Keyword (fr)
- Biphényle dérivé In vitro Inhibiteur enzyme Isozyme Modèle moléculaire Modélisation Protein-tyrosine-phosphatase Relation structure activité Site fixation Structure cristalline Synthèse chimique 1,2,5-Thiadiazolidin-3-one(5-[4-méthoxy-biphényl-3-yl])-1,1-dioxyde 1,2,5-Thiadiazolidine dérivé Enzyme Esterases Hydrolases Phosphoric monoester hydrolases
- Keyword (en)
- Biphenyl derivatives In vitro Enzyme inhibitor Isozyme Molecular model Modeling Protein-tyrosine-phosphatase Structure activity relation Binding site Crystalline structure Chemical synthesis Enzyme Esterases Hydrolases Phosphoric monoester hydrolases
- Keyword (es)
- Bifenilo derivado In vitro Inhibidor enzima Isozima Modelo molecular Modelización Protein-tyrosine-phosphatase Relación estructura actividad Sitio fijación Estructura cristalina Síntesis química Enzima Esterases Hydrolases Phosphoric monoester hydrolases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16746155
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.03.068 
https://dx.doi.org/10.1016/j.bmcl.2005.03.068
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