Synthesis and pharmacology of 6-substituted benztropines : Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter
- Author
- SIMONI, Daniele1 ; ROSSI, Marcello1 ; MERIGHI, Stefania6 ; VARANI, Katia6 ; GESSI, Stefania6 ; BOREA, Pier Andrea6 ; MARINO, Silvia6 ; CAVALLINI, Sabrina6 ; BIANCHI, Clementina6 ; SINISCALCHI, Anna6 ; BERTOLASI, Valerio2 ; ROBERTI, Marinella3 ; PIZZIRANI, Daniela3 ; RONDANIN, Riccardo1 ; BARUCHELLO, Riccardo1 ; INVIDIATA, Francesco Paolo4 ; TOLOMEO, Manlio5 ; GRIMAUDO, Stefania5
[1] Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Via Fossato di Mortara 17-19, 44100 Ferrara, Italy
[2] Dipartimento di Chimica, Universita di Ferrara, Italy
[3] Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy
[4] Dipartimento Farmacochimico Tossicologico e Biologico, Universita di Palermo, Italy
[5] Divisione di Ematologia e Servizio A.I.D.S., Policlinico, Universita di Palermo, Italy
[6] Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Universita di Ferrara, Italy - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 9, pp 3337-3343, 7 p ; ref : 24 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Antiparkinsonien Benzatropine Catécholamine Dopamine Fixation biologique In vitro Inhibiteur recapture Neurotransmetteur Protéine transport Synthèse chimique Système nerveux central Transport membranaire Tropane dérivé 8-Azabicyclo[3.2.1]octane dérivé 8-Azabicyclo[3.2.1]octane(3α-[4,4p-difluorobenzhydryloxy]-6α-méthoxy-8-méthyl) Inhibiteur recapture dopamine Transporteur dopamine
- Keyword (en)
- Biological activity Antiparkinson agent Benzatropine Catecholamine Dopamine Biological fixation In vitro Reuptake inhibitor Neurotransmitter Carrier protein Chemical synthesis Central nervous system Membrane transport Tropane derivatives
- Keyword (es)
- Actividad biológica Antiparkinsoniano Benzatropina Catecolamina Dopamina Fijación biológica In vitro Inhibidor recaptura Neurotransmisor Proteína transportador Síntesis química Sistema nervioso central Transporte membranal
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B06 Anticonvulsants. Antiepileptics. Antiparkinson agents
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16758010
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1021/jm0490235 
https://dx.doi.org/10.1021/jm0490235
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm0490235\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:164:\"Synthesis and pharmacology of 6-substituted benztropines : Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"48\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:4:\"3337\";s:8:\"\u0000*\u0000epage\";s:4:\"3343\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"SIMONI\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Daniele\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:17:{i:0;s:15:\"ROSSI, Marcello\";i:1;s:17:\"MERIGHI, Stefania\";i:2;s:13:\"VARANI, Katia\";i:3;s:15:\"GESSI, Stefania\";i:4;s:18:\"BOREA, Pier Andrea\";i:5;s:14:\"MARINO, Silvia\";i:6;s:18:\"CAVALLINI, Sabrina\";i:7;s:19:\"BIANCHI, Clementina\";i:8;s:17:\"SINISCALCHI, Anna\";i:9;s:18:\"BERTOLASI, Valerio\";i:10;s:18:\"ROBERTI, Marinella\";i:11;s:18:\"PIZZIRANI, Daniela\";i:12;s:18:\"RONDANIN, Riccardo\";i:13;s:20:\"BARUCHELLO, Riccardo\";i:14;s:26:\"INVIDIATA, Francesco Paolo\";i:15;s:15:\"TOLOMEO, Manlio\";i:16;s:18:\"GRIMAUDO, Stefania\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:164:\"Synthesis and pharmacology of 6-substituted benztropines : Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"7\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm0490235\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:164:\"Synthesis and pharmacology of 6-substituted benztropines : Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"48\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:4:\"3337\";s:8:\"\u0000*\u0000epage\";s:4:\"3343\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"SIMONI\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Daniele\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:17:{i:0;s:15:\"ROSSI, Marcello\";i:1;s:17:\"MERIGHI, Stefania\";i:2;s:13:\"VARANI, Katia\";i:3;s:15:\"GESSI, Stefania\";i:4;s:18:\"BOREA, Pier Andrea\";i:5;s:14:\"MARINO, Silvia\";i:6;s:18:\"CAVALLINI, Sabrina\";i:7;s:19:\"BIANCHI, Clementina\";i:8;s:17:\"SINISCALCHI, Anna\";i:9;s:18:\"BERTOLASI, Valerio\";i:10;s:18:\"ROBERTI, Marinella\";i:11;s:18:\"PIZZIRANI, Daniela\";i:12;s:18:\"RONDANIN, Riccardo\";i:13;s:20:\"BARUCHELLO, Riccardo\";i:14;s:26:\"INVIDIATA, Francesco Paolo\";i:15;s:15:\"TOLOMEO, Manlio\";i:16;s:18:\"GRIMAUDO, Stefania\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:164:\"Synthesis and pharmacology of 6-substituted benztropines : Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"7\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm0490235\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm0490235\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:164:\"Synthesis and pharmacology of 6-substituted benztropines : Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"48\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:4:\"3337\";s:8:\"\u0000*\u0000epage\";s:4:\"3343\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"SIMONI\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Daniele\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:17:{i:0;s:15:\"ROSSI, Marcello\";i:1;s:17:\"MERIGHI, Stefania\";i:2;s:13:\"VARANI, Katia\";i:3;s:15:\"GESSI, Stefania\";i:4;s:18:\"BOREA, Pier Andrea\";i:5;s:14:\"MARINO, Silvia\";i:6;s:18:\"CAVALLINI, Sabrina\";i:7;s:19:\"BIANCHI, Clementina\";i:8;s:17:\"SINISCALCHI, Anna\";i:9;s:18:\"BERTOLASI, Valerio\";i:10;s:18:\"ROBERTI, Marinella\";i:11;s:18:\"PIZZIRANI, Daniela\";i:12;s:18:\"RONDANIN, Riccardo\";i:13;s:20:\"BARUCHELLO, Riccardo\";i:14;s:26:\"INVIDIATA, Francesco Paolo\";i:15;s:15:\"TOLOMEO, Manlio\";i:16;s:18:\"GRIMAUDO, Stefania\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:164:\"Synthesis and pharmacology of 6-substituted benztropines : Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"7\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm0490235\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:164:\"Synthesis and pharmacology of 6-substituted benztropines : Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2005\";s:9:\"\u0000*\u0000volume\";s:2:\"48\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:4:\"3337\";s:8:\"\u0000*\u0000epage\";s:4:\"3343\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"SIMONI\";s:10:\"\u0000*\u0000aufirst\";s:7:\"Daniele\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:17:{i:0;s:15:\"ROSSI, Marcello\";i:1;s:17:\"MERIGHI, Stefania\";i:2;s:13:\"VARANI, Katia\";i:3;s:15:\"GESSI, Stefania\";i:4;s:18:\"BOREA, Pier Andrea\";i:5;s:14:\"MARINO, Silvia\";i:6;s:18:\"CAVALLINI, Sabrina\";i:7;s:19:\"BIANCHI, Clementina\";i:8;s:17:\"SINISCALCHI, Anna\";i:9;s:18:\"BERTOLASI, Valerio\";i:10;s:18:\"ROBERTI, Marinella\";i:11;s:18:\"PIZZIRANI, Daniela\";i:12;s:18:\"RONDANIN, Riccardo\";i:13;s:20:\"BARUCHELLO, Riccardo\";i:14;s:26:\"INVIDIATA, Francesco Paolo\";i:15;s:15:\"TOLOMEO, Manlio\";i:16;s:18:\"GRIMAUDO, Stefania\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:164:\"Synthesis and pharmacology of 6-substituted benztropines : Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"7\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
