Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity
- Author
- SOUERS, Andrew J1 ; JU GAO1 ; SHAPIRO, Robin1 ; HERNANDEZ, Lisa E1 ; MARSH, Kennan C1 ; SHAM, Hing L1 ; COLLINS, Christine A1 ; KYM, Philip R1 ; WODKA, Dariusz1 ; JUDD, Andrew S1 ; MULHERN, Mathew M1 ; NAPIER, James J1 ; BRUNE, Michael E1 ; BUSH, Eugene N1 ; BRODJIAN, Sevan J1 ; DAYTON, Brian D1
[1] Metabolic Disease Research, Abbott Laboratories, 100 Ahhott Park Road, Abbott Park, IL 60064, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 11, pp 2752-2757, 6 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- MCHR1 Obesity
- Keyword (fr)
- Affinité Animal Anorexigène Antagoniste Benzène dérivé Chimiothérapie Chronique Composé aromatique Composé bicyclique Cycle 5 chaînons Ether Hormone concentrant mélanine Hétérocycle azote In vitro In vivo Indazole dérivé Obésité Pharmacocinétique Pyrrolidine dérivé Relation structure activité Récepteur hormonal Souris Synthèse chimique Traitement Trouble nutrition Urées Voie orale Imidazol-2-one(1-[4-phénoxyphényl]-3-[1-(2-pyrrolidinoéthyl)indazol-5-yl]) Récepteur MCH1 Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Animal Anorectic Antagonist Benzene derivatives Chemotherapy Chronic Aromatic compound Bicyclic compound Five membered ring Ether Melanin concentrating hormone Nitrogen heterocycle In vitro In vivo Indazole derivatives Obesity Pharmacokinetics Pyrrolidine derivatives Structure activity relation Hormonal receptor Mouse Chemical synthesis Treatment Nutrition disorder Ureas Oral administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Animal Anorexígeno Antagonista Benceno derivado Quimioterapia Crónico Compuesto aromático Compuesto bicíclico Ciclo 5 eslabones Eter Hormona concentración melanina Heterociclo nitrógeno In vitro In vivo Indazol derivado Obesidad Farmacocinética Relación estructura actividad Receptor hormonal Ratón Síntesis química Tratamiento Trastorno nutricíon Ureas Vía oral Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02O Hormones. Endocrine system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16810660
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.03.114 
https://dx.doi.org/10.1016/j.bmcl.2005.03.114
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