Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones : selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
- Author
- JASON XIANG1 ; IPEK, Manus1 ; TAM, Steve1 ; SURI, Vipin2 ; MASSEFSKI, Walt1 ; NING PAN1 ; YING GE1 ; TARN, May2 ; YUZHE XING2 ; TOBIN, James F2 ; XIN XU3
[1] Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, MA 02140, United States
[2] Cardiovascular and Metabolic Diseases, Wyeth Research, 200 Cambridge Park Drive, MA 02140, United States
[3] Drug Safety and Metabolism. Wveth Research. 200 Cambridge Park Drive, MA 02140, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 11, pp 2865-2869, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- 11β-HSD1 Inhibitor Sulfonamidooxazole β-Keto sulfone
- Keyword (fr)
- 11β-Hydroxysteroid dehydrogenase Benzène dérivé Biphényle dérivé Cycle 5 chaînons Cétosulfone Diabète type 2 Fluor Composé organique Hétérocycle oxygène azote Inhibiteur enzyme Oxazole dérivé Relation structure activité Sulfonamide Sulfone Synthèse chimique Sélectivité Trouble métabolisme Acétophénone(2-benzènesulfonyl-4p-trifluorométhyl) Benzèensulfonamide(N-[4-biphényl-4-yloxazol-2-yl]) Enzyme Oxidoreductases
- Keyword (en)
- 11β-Hydroxysteroid dehydrogenase Benzene derivatives Biphenyl derivatives Five membered ring Oxosulfone Type 2 diabetes Fluorine Organic compounds Oxygen nitrogen heterocycle Enzyme inhibitor Oxazole derivatives Structure activity relation Sulfonamide Sulfone Chemical synthesis Selectivity Metabolic disorder Enzyme Oxidoreductases
- Keyword (es)
- 11β-Hydroxysteroid dehydrogenase Benceno derivado Bifenilo derivado Ciclo 5 eslabones Cetosulfona Diabetes de tipo 2 Fluor Compuesto orgánico Heterociclo oxígeno nitrógeno Inhibidor enzima Oxazol derivado Relación estructura actividad Sulfonamida Sulfona Síntesis química Selectividad Trastorno metabolismo Enzima Oxidoreductases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16810676
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.03.093 
https://dx.doi.org/10.1016/j.bmcl.2005.03.093
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