Protein farnesyltransferase inhibitors exhibit potent antimalarial activity
- Author
- NALLAN, Laxman1 ; BAUER, Kevin D2 ; HAMILTON, Andrew; SEBTI, Said; WINDSOR, William T; WEBER, Patricia C; BUCKNER, Frederick S2 ; CHAKRABARTI, Debopam3 ; GELB, Michael H1 ; VAN VOORHIS, Wesley C2 ; BENDALE, Pravin1 ; RIVAS, Kasey2 ; YOKOYAMA, Kohei1 ; HORNEY, Carolyn P2 ; RAO PENDYALA, Prakash3 ; FLOYD, David4 ; LOMBARDO, Louis J4 ; WILLIAMS, David K4
[1] Department of Chemistry, University of Washington, Seattle, Washington 98195, United States
[2] Department of Medicine, University of Washington, Seattle, Washington 98195, United States
[3] Department of Molecular Biology and Microbiology, University of Central Florida, Orlando, Florida 32826, United States
[4] Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, United States - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 11, pp 3704-3713, 10 p ; ref : 27 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Aminoester Animal Antipaludique Antiparasitaire Antiprotozoaire Chimiothérapie Composé aromatique Composé bicyclique Cycle 5 chaînons Farnesyl-diphosphate farnesyltransferase Hétérocycle azote Imidazole dérivé In vitro In vivo Inhibiteur enzyme Nitrile Paludisme Plasmodium berghei Plasmodium falciparum Quinoléine dérivé Relation structure activité Souris Synthèse chimique Traitement Voie intrapéritonéale α-Aminoacide Glycine(N-[6-cyano-1-([1-méthylimidazol-5-yl]méthyl)-1,2,3,4-tétrahydro-3-quinolyl]-N-[(1-méthylimidazol-4-yl)sulfonyl]) ester t-butyle Imidazole-4-sulfonamide(N-[6-cyano-1-([1-méthylimidazol-5-yl]méthyl)-1,2,3,4-tétrahydro-3-quinolyl]-N-isobutyl-1-méthyl) Apicomplexa Enzyme Infection Mammalia Parasitose Protozoa Protozoose Rodentia Transferases Vertebrata
- Keyword (en)
- Aminoester Animal Antimalarial Parasiticide Antiprotozoal agent Chemotherapy Aromatic compound Bicyclic compound Five membered ring Farnesyl-diphosphate farnesyltransferase Nitrogen heterocycle Imidazole derivatives In vitro In vivo Enzyme inhibitor Nitrile Malaria Plasmodium berghei Plasmodium falciparum Quinoline derivatives Structure activity relation Mouse Chemical synthesis Treatment Intraperitoneal administration α-Aminoacid Apicomplexa Enzyme Infection Mammalia Parasitosis Protozoa Protozoal disease Rodentia Transferases Vertebrata
- Keyword (es)
- Aminoester Animal Antipalúdico Antiparasitario Antiprotozoario Quimioterapia Compuesto aromático Compuesto bicíclico Ciclo 5 eslabones Farnesyl-diphosphate farnesyltransferase Heterociclo nitrógeno Imidazol derivado In vitro In vivo Inhibidor enzima Nitrilo Paludismo Plasmodium berghei Plasmodium falciparum Quinolina derivado Relación estructura actividad Ratón Síntesis química Tratamiento Vía intraperitoneal α-Aminoácido Apicomplexa Enzima Infección Mammalia Parasitosis Protozoa Protozoosis Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16812134
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm0491039 
https://dx.doi.org/10.1021/jm0491039
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