Synthesis, antiviral activity, and mechanism of drug resistance of D- and L-2',3'-didehydro-2',3'-dideoxy-2'-fluorocarbocyclic nucleosides
- Author
- JIANING WANG1 ; YUNHO JIN1 ; RAPP, Kimberly L2 ; BENNETT, Matthew2 ; SCHINAZI, Raymond F2 ; CHU, Chung K1
[1] College of Pharmacy, The University of Georgia, Athens, Georgia 30602, United States
[2] Emory University School of Medicine/Veterans Affairs Medical Center, Atlanta, Georgia 30033, United States - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 11, pp 3736-3748, 13 p ; ref : 22 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Analogue nucléoside Antiviral Complexe enzyme inhibiteur Composé monocyclique Composé éthylénique Didésoxynucléoside In vitro Lamivudine Mode liaison Modèle moléculaire Modélisation Mécanisme Purine nucléoside Pyrimidine nucléoside Relation structure activité Résistance traitement Site actif Stéréoisomère Synthèse chimique Virus HIV1 Cyclopent-2-èneméthanol dérivé Enzyme Fluor Composé organique Inhibiteur enzyme Inhibiteur reverse transcriptase Lentivirus Nucleotidyltransferases RNA-directed DNA polymerase Retroviridae Transferases Virus immunodéficience humaine Virus
- Keyword (en)
- Nucleoside analog Antiviral Inhibitor enzyme complex Monocyclic compound Ethylenic compound Dideoxynucleoside In vitro Lamivudine Binding mode Molecular model Modeling Mechanism Purine nucleoside Pyrimidine nucleoside Structure activity relation Treatment resistance Active site Stereoisomer Chemical synthesis HIV-1 virus Enzyme Fluorine Organic compounds Enzyme inhibitor Reverse transcriptase inhibitor Lentivirus Nucleotidyltransferases RNA-directed DNA polymerase Retroviridae Transferases Human immunodeficiency virus Virus
- Keyword (es)
- Análogo nucleósido Antiviral Complejo enzima inhibidor Compuesto monocíclico Compuesto etilénico Didesoxinucleósido In vitro Lamivudina Modo de enlace Modelo molecular Modelización Mecanismo Purina nucleósido Pirimidina nucleósido Relación estructura actividad Resistencia tratamiento Lugar activo Estereoisómero Síntesis química HIV-1 virus Enzima Fluor Compuesto orgánico Inhibidor enzima Inhibitor reverse transcriptase Lentivirus Nucleotidyltransferases RNA-directed DNA polymerase Retroviridae Transferases Human immunodeficiency virus Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16812137
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm050096d 
https://dx.doi.org/10.1021/jm050096d
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