Synthesis of gossypol atropisomers and derivatives and evaluation of their anti-proliferative and anti-oxidant activity
- Author
- DODOU, Kalliopi1 ; ANDERSON, Rosaleen J1 ; LOUGH, W. John1 ; SMALL, David A. P2 ; SHELLEY, Michael D3 ; GROUNDWATER, Paul W1
[1] Sunderland Pharmacy School, University of Sunderland, Wharncliffe Street, Sunderland SR1 3SD, United Kingdom
[2] Stiefel International R&D, Whitebrook Park, 68 Lower Cookham Road, Maidenhead, Berkshire SL6 8XY, United Kingdom
[3] Velindre NHS Trust, Whitchurch, Cardiff CF14 2TL, United Kingdom - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 13, pp 4228-4237, 10 p ; ref : 40 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Anti- proliferative Anti-oxidant Atropisomers Gossypol Psoriasis
- Keyword (fr)
- Activité biologique Aldéhydophénols Antioxydant Antipsoriasique Atropisomérie Base Schiff Gossypol Imine In vitro Inhibiteur Kératinocyte Lignée cellulaire Lipide Multiplication cellulaire Peroxydation Synthèse chimique 2,2p-Binaphtyle dérivé Lignée HPV16 Tyrosine dérivé
- Keyword (en)
- Biological activity Aldehydophenols Antioxidant Antipsoriatic agent Atropoisomerism Schiff base Gossypol Imine In vitro Inhibitor Keratinocyte Cell line Lipids Cell proliferation Peroxidation Chemical synthesis
- Keyword (es)
- Actividad biológica Aldehidofenoles Antioxidante Antipsoriásico Atropoisomería Base Schiff Gosipol Imina In vitro Inhibidor Queratinocito Línea celular Lípido Multiplicación celular Peroxidación Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02K Skin, nail, hair, dermoskeleton
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16845484
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2005.04.026 
https://dx.doi.org/10.1016/j.bmc.2005.04.026
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