Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors
- Author
- MARING, Clarence J; STOLL, Vincent S; MONTGOMERY, Debra A; KEMPF-GROTE, Anita; MARSH, Kennan C; MOLLA, Akhteruzzaman; STEFFY, Kevin R; SHAM, Hing L; LAVER, W. Graeme1 ; GU, Yu-Gui; KEMPF, Dale J; KOHLBRENNER, William E; CHEN ZHAO; MINGHUA SUN; KRUEGER, Allan C; STEWART, Kent D; MADIGAN, Darold L; KATI, Warren M; YIBO XU; CARRICK, Robert J
Departments of Infectious Disease Research and Advanced Technology, Global Pharmaceutical R & D, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, Illinois 60064, United States
[1] John Curtin School of Medical Research, the Australian National University, Canberra 260, Australia - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 12, pp 3980-3990, 11 p ; ref : 35 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antiviral Biodisponibilité Diffraction RX Exo-α-sialidase Grippe Inhibiteur enzyme Inhibiteur neuraminidase Interaction hydrophobe Modèle moléculaire Modélisation Optimisation Pharmacocinétique Promédicament Pyrrolidine dérivé Rat Relation structure activité Site actif Structure cristalline Structure moléculaire Synthèse chimique Voie orale Proline dérivé Pyrrolidine-2-carboxamide(5-[1-acétamido-3-méthylbutyl]-4-[2-méthylprop-1-ényl]) Enzyme Glycosidases Hydrolases Infection Mammalia O-Glycosidases Rodentia Vertebrata Virose
- Keyword (en)
- Animal Antiviral Bioavailability X ray diffraction Exo-α-sialidase Influenza Enzyme inhibitor Neuraminidase inhibitor Hydrophobic interaction Molecular model Modeling Optimization Pharmacokinetics Prodrug Pyrrolidine derivatives Rat Structure activity relation Active site Crystalline structure Molecular structure Chemical synthesis Oral administration Enzyme Glycosidases Hydrolases Infection Mammalia O-Glycosidases Rodentia Vertebrata Viral disease
- Keyword (es)
- Animal Antiviral Biodisponibilidad Difracción RX Exo-α-sialidase Gripe Inhibidor enzima Inhibidor neuraminidasa Modelo molecular Modelización Optimización Farmacocinética Promedicamento Rata Relación estructura actividad Lugar activo Estructura cristalina Estructura molecular Síntesis química Vía oral Enzima Glycosidases Hydrolases Infección Mammalia O-Glycosidases Rodentia Vertebrata Virosis
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16856763
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm049276y 
https://dx.doi.org/10.1021/jm049276y
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