Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
- Author
- VAN ES, Johan H1 ; VAN GIJN, Marielle E1 ; CLEVERS, Hans1 ; RICCIO, Orbicia2 ; VAN DEN BORN, Maaike1 ; VOOIJS, Marc1 ; BEGTHEL, Harry1 ; COZIJNSEN, Miranda1 ; ROBINE, Sylvie3 ; WINTON, Doug J4 ; RADTKE, Freddy2
[1] Hubrecht Laboratory, Netherlands Institute for Developmental Biology. Uppsalalaan 8, 3584CT Utrecht, Netherlands
[2] Ludwig Institute for Cancer Research, Chemin de Boveresses 155, 1066 Epalinges, Switzerland
[3] Morphogenesis and Intracellular Signaling, Institut Curie-CNRS-UMR 144, Paris 75248, France
[4] Cancer Research UK Department of Oncology, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, United Kingdom - Source
Nature (London). 2005, Vol 435, Num 7044, pp 959-963, 5 p ; ref : 29 ref
- CODEN
- NATUAS
- ISSN
- 0028-0836
- Scientific domain
- Multidisciplinary
- Publisher
- Nature Publishing, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Adénome colorectal Animal Anticancéreux Cancérologie Cellule caliciforme Cytodifférenciation Glande Lieberkuhn Gène Inhibiteur enzyme Multiplication cellulaire Souris Gène Notch Secretase gamma Appareil digestif pathologie Côlon pathologie Enzyme Génétique Intestin pathologie Mammalia Rectum pathologie Rodentia Tumeur bénigne Vertebrata
- Keyword (en)
- Colorectal adenoma Animal Antineoplastic agent Cancerology Goblet cell Cell differentiation Lieberkuhn gland Gene Enzyme inhibitor Cell proliferation Mouse Digestive diseases Colonic disease Enzyme Genetics Intestinal disease Mammalia Rectal disease Rodentia Benign neoplasm Vertebrata
- Keyword (es)
- Adenoma colorectal Animal Anticanceroso Cancerología Célula caliciforme Diferenciación celular Glándula Lieberkuhn Gen Inhibidor enzima Multiplicación celular Ratón Aparato digestivo patología Colón patología Enzima Genética Intestino patología Mammalia Recto patología Rodentia Tumor benigno Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16877750
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nature03659 
https://dx.doi.org/10.1038/nature03659
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