Synthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)
- Author
- ROWBOTTOM, Martin W1 ; VICKERS, Troy D1 ; MISTRY, Monica4 ; FISHER, Andrew5 ; DONG, Teresa5 ; TAO HU1 ; SAUNDERS, John1 ; GOODFELLOW, Val S1 ; DYCK, Brian1 ; TAMIYA, Junko1 ; MINGZHU ZHANG1 ; LIREN ZHAO1 ; GREY, Jonathan1 ; PROVENCAL, David2 ; SCHWARZ, David3 ; HEISE, Christopher E4
[1] Department of Medicinal Chemistry, Neurocrine Biosciences Inc., 12790 El Camino Real, San Diego, CA 92130, United States
[2] Department of Process Chemistry, Neurocrine Biosciences Inc., 12790 El Camino Real, San Diego, CA 92130, United States
[3] Department of Molecular Biology, Neurocrine Biosciences Inc., 12790 El Camino Real, San Diego, CA 92130, United States
[4] Department of Pharmacology, Neurocrine Biosciences Inc., 12790 El Camino Real, San Diego, CA 92130, United States
[5] Department of Preclinical Development, Neurocrine Biosciences Inc., 12790 El Camino Real, San Diego, CA 92130, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 14, pp 3439-3445, 7 p ; ref : 19 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- MCH antagonists MCH Melanin-concentrating hormone Obesity
- Keyword (fr)
- Affinité Antagoniste Benzène dérivé Cycle 5 chaînons Hormone concentrant mélanine Hétérocycle azote In vitro Molécule petite Obésité Relation structure activité Récepteur hormonal Résistance hydrolyse Synthèse chimique Urées Pyrrolidine-2-carboxamide(3-[aroyl méthyl amino]-N-[N-méthyl-N-(1-méthylpyrrolidin-3-yl)]) Récepteur MCH1 Trouble nutrition
- Keyword (en)
- Affinity Antagonist Benzene derivatives Five membered ring Melanin concentrating hormone Nitrogen heterocycle In vitro Small molecule Obesity Structure activity relation Hormonal receptor Hydrolysis resistance Chemical synthesis Ureas Nutrition disorder
- Keyword (es)
- Afinidad Antagonista Benceno derivado Ciclo 5 eslabones Hormona concentración melanina Heterociclo nitrógeno In vitro Molécula pequeña Obesidad Relación estructura actividad Receptor hormonal Resistencia hidrólisis Síntesis química Ureas Trastorno nutricíon
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02O Hormones. Endocrine system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16903903
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.05.015 
https://dx.doi.org/10.1016/j.bmcl.2005.05.015
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