Structure-driven HtL : Design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity
- Author
- STOCKS, Michael J1 ; BARBER, Simon1 ; FORD, Rhonan1 ; LEROUX, Frederic1 ; ST-GALLAY, Steve2 ; TEAGUE, Simon1 ; YAFENG XUE3
[1] Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bake-well Road, Loughborough LE11 5RH, United Kingdom
[2] Department of Physical and Metabolic Science, AstraZeneca R&D Charnwood, Bake-well Road, Loughborough LE11 5RH, United Kingdom
[3] Structural Chemistry Laboratory, AstraZeneca R&D Mölndal, 431 83, Mölndal, Sweden - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 14, pp 3459-3462, 4 p ; ref : 18 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Aminoindazole Bioavailable Inhibitors c-Jun N-terminal kinase
- Keyword (fr)
- Animal Benzène dérivé Biodisponibilité Complexe enzyme inhibiteur Composé bicyclique Criblage haut débit Ether Hétérocycle azote In vitro Indazole dérivé Inhibiteur enzyme Mitogen-activated protein kinase Modèle moléculaire Modélisation Pharmacocinétique Protein kinase Rat Relation structure activité Site fixation Structure cristalline Synthèse chimique Transduction signal Indazole(3-[(2,5-diméthoxybenzyl)amino]-4-phénoxy) Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Animal Benzene derivatives Bioavailability Inhibitor enzyme complex Bicyclic compound High throughput screening Ether Nitrogen heterocycle In vitro Indazole derivatives Enzyme inhibitor Mitogen-activated protein kinase Molecular model Modeling Pharmacokinetics Protein kinase Rat Structure activity relation Binding site Crystalline structure Chemical synthesis Signal transduction Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Animal Benceno derivado Biodisponibilidad Complejo enzima inhibidor Compuesto bicíclico Cribado alta productividad Eter Heterociclo nitrógeno In vitro Indazol derivado Inhibidor enzima Mitogen-activated protein kinase Modelo molecular Modelización Farmacocinética Protein kinase Rata Relación estructura actividad Sitio fijación Estructura cristalina Síntesis química Transducción señal Enzima Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16903907
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.05.008 
https://dx.doi.org/10.1016/j.bmcl.2005.05.008
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