Synthesis and evaluation of (17α,20Z)-21-(4-substituted-phenyl)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diols as ligands for the estrogen receptor-a hormone binding domain : Comparison with 20E-isomers
- Author
- HANSON, Robert N1 2 ; FRIEL, Carolyn J2 ; DILIS, Robert1 ; HUGHES, Alun3 ; DESOMBRE, Eugene R3
[1] Department of Chemistry, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115-5000, United States
[2] Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115-5000, United States
[3] The Ben May Institute for Cancer Research, The University of Chicago, 5485 South Maryland Avenue, Chicago, Illinois 60637, United States - Source
Journal of medicinal chemistry (Print). 2005, Vol 48, Num 13, pp 4300-4311, 12 p ; ref : 56 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide carboxylique Acétophénone dérivé Affinité Agoniste Benzonitrile dérivé Benzoïque acide dérivé Benzène dérivé Composé aromatique Cétone Energie liaison Ether Etude comparative In vitro Isomère Modèle moléculaire Modélisation Nitrile Phénols Propriété thermodynamique Relation structure activité Récepteur hormonal Récepteur oestrogène α Site fixation Stéréoisomère Synthèse chimique 19-Norprégna-1,3,5(10),20-tétraène-3,17β-diol(21-aryl) Fluor Composé organique
- Keyword (en)
- Carboxylic acid Acetophenone derivatives Affinity Agonist Benzonitrile derivatives Benzoic acid derivatives Benzene derivatives Aromatic compound Ketone Binding energy Ether Comparative study In vitro Isomer Molecular model Modeling Nitrile Phenols Thermodynamic properties Structure activity relation Hormonal receptor Estrogen receptor α Binding site Stereoisomer Chemical synthesis Fluorine Organic compounds
- Keyword (es)
- Acido carboxílico Acetofenona derivado Afinidad Agonista Benzonitrilo derivado Benzoico ácido derivado Benceno derivado Compuesto aromático Cetona Energía enlace Eter Estudio comparativo In vitro Isómero Modelo molecular Modelización Nitrilo Fenoles Propiedad termodinámica Relación estructura actividad Receptor hormonal Receptor estrógeno α Sitio fijación Estereoisómero Síntesis química Fluor Compuesto orgánico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02O Hormones. Endocrine system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16917854
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm040157s 
https://dx.doi.org/10.1021/jm040157s
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