Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles
- Author
- MILLER, John F1 ; BRIEGER, Michael1 ; FURFINE, Eric S1 ; HAZEN, Richard J1 ; KALDOR, Istvan1 ; REYNOLDS, David1 ; SHERRILL, Ronald G1 ; SPALTENSTEIN, Andrew1
[1] GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2005, Vol 15, Num 15, pp 3496-3500, 5 p ; ref : 12 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Antiretroviral Antiviral Arylsulfonamide Drug resistance HIV protease Hypersusceptibility
- Keyword (fr)
- Acétal Alcool secondaire Animal Antiviral Biodisponibilité Carbamate organique Chien Composé aromatique Composé bicyclique Composé non peptide Composé peptidomimétique Hétérocycle oxygène In vitro In vivo Inhibiteur enzyme Inhibiteur protease Peptidases Pharmacocinétique Rat Relation structure activité Sulfonamide Synthèse chimique Urées Virus immunodéficience humaine 1,3-Benzodioxole-5-sulfonamide dérivé Benzènesulfonamide dérivé Furo[2,3-b]furane dérivé Furofurane Carnivora Enzyme Fissipedia Hydrolases Lentivirus Mammalia Retroviridae Rodentia Vertebrata Virus
- Keyword (en)
- Acetal Secondary alcohol Animal Antiviral Bioavailability Organic carbamate Dog Aromatic compound Bicyclic compound Non peptide compound Peptidomimetic compound Oxygen heterocycle In vitro In vivo Enzyme inhibitor Protease inhibitor Peptidases Pharmacokinetics Rat Structure activity relation Sulfonamide Chemical synthesis Ureas Human immunodeficiency virus Carnivora Enzyme Fissipedia Hydrolases Lentivirus Mammalia Retroviridae Rodentia Vertebrata Virus
- Keyword (es)
- Acetal Alcohol secundario Animal Antiviral Biodisponibilidad Carbamato orgánico Perro Compuesto aromático Compuesto bicíclico Compuesto no péptido Compuesto peptidomimético Heterociclo oxígeno In vitro In vivo Inhibidor enzima Inhibidor proteasa Peptidases Farmacocinética Rata Relación estructura actividad Sulfonamida Síntesis química Ureas Human immunodeficiency virus Carnivora Enzima Fissipedia Hydrolases Lentivirus Mammalia Retroviridae Rodentia Vertebrata Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16919876
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.05.129 
https://dx.doi.org/10.1016/j.bmcl.2005.05.129
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